BMI Seminar // Novel treatment strategies for deficient fear extinction learning
Event details
Date | 08.03.2017 |
Hour | 12:15 › 13:15 |
Speaker | Nicolas Singewald, Department of Pharmacology and Toxicology, University of Innsbruck, Austria |
Location | |
Category | Conferences - Seminars |
With existing treatments of fear-, anxiety- and trauma-related disorders - the most prevalent mental disorders - a considerable proportion of patients shows only partial long-term therapeutic benefit. A promising option in improving therapy is the pharmacological boosting of exposure-based therapy (EBT). I will show general concepts of treatment improvement based on accumulating neuroscientific knowledge concerning the neurocircuitries and neurobiological mechanisms underlying fear learning and fear inhibition. Select examples of novel strategies in augmenting fear extinction, the central mechanisms of EBT. underlying successful fear extinction, will be presented, The examples discussed will include deep brain stimulation, targeting micro RNAs, as well drugs such as L‑DOPA, D‑cycloserine and HDAC inhibitors to facilitate the building of extinction memory. Neuropeptide S will be presented as a model substance with anxiolytic and extinction-facilitating properties. The presented mechanisms represent promising drug development targets for augmenting the efficacy and improving the acceptance of EBT in the treatment of anxiety disorders.
Practical information
- Informed public
- Free
Organizer
- SV BMI Hosts : J. Gräff & C. Sandi