BMI Seminar // The power to sense and signal: Mitochondrial regulation of stress responses
Event details
| Date | 26.04.2017 |
| Hour | 12:15 › 13:15 |
| Speaker | Martin Picard, Dept of Psychiatry and Neurology, Division of Behavioral Medicine, Columbia Translational Neuroscience Initiative, Columbia University, New York, USA |
| Location | |
| Category | Conferences - Seminars |
In addition to producing energy, mitochondria perform a number of biochemical and signaling functions. Recent evidence suggests that, like neurons in neural networks, mitochondria sense, integrate, and signal. Mitochondria thereby transmit information about external stressors and translate it into molecular and physiological responses. To understand how this influences gene expression and multisystemic neuroendocrine responses to psychological stress, we genetically manipulated different mitochondrial functions in cells and mice. This work shows that mitochondria regulate the nature and magnitude of cellular and systemic stress responses. Additional studies in tissues of patients with mitochondrial DNA diseases reveal the existence of both novel mitochondrial structures and abnormal sub-cellular behavior in response to genetic stress. Together, these studies provide converging evidence for a heretofore unsuspected role of mitochondrial signaling from organelle to organism.
Practical information
- Informed public
- Free
Organizer
- EPFL SV BMI Host : C. Sandi