\r\nRegistration link\r\n
![\"\"](\"https://www.epfl.ch/research/domains/synapsy-research-center/wp-content/uploads/2026/06/Project-Poster-Sympo-Oct-7-2026.gif\")
\r\nEine App programmieren? Ein Computerspiel erfinden? Eine Animation gestalten?
\r\nWenn dich eines dieser Dinge interessiert, bist du hier am richtigen Ort! Tausche und teile deine Ideen, lerne zu programmieren und entdecke Informatikberufe.
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\r\nDie Coding Club for Girls Workshops sind für Mädchen im Alter von 11 bis 15 Jahren und die Teilnahme ist kostenlos. Ab der Teilnahme an vier Workshops pro Jahr wird eine Teilnahmebestätigung ausgehändigt.
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\r\nOrt: Benedict Schule, Bern
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\r\nDatum und Zeit:
\r\n05. September 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Scratch-me
\r\n12. September 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Minitel
\r\n17. Oktober 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Snake-it
\r\n24. Oktober 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Webdesignerin
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\r\nDie Inhalte der Workshops sind untenstehend beschrieben.
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\r\nBedingungen\r\n
How can we meaningfully interpret neuronal calcium imaging data? Calcium imaging is one of the key methods used to record neuronal activity from the brain of animals. I will outline why the interpretation of calcium signals remains a major bottleneck in understanding neuronal activity and plasticity. I will trace the origins of this problem and how partial solutions have been provided by my own and by others' work, and how these issues are affected by recording conditions and different calcium indicators (e.g., OGB-1, GCaMP6, GCaMP8). I will propose a conceptual path forward that could make calcium imaging a more powerful tool than it currently is.
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This symposium, taking place on October 7, 2026 on the EPFL campus, aims to connect two rapidly advancing fields that too often remain separated: resilience to life stress (allostasis, plasticity and adaptation across body systems) and resilience to cognitive decline (cognitive reserve, brain maintenance and mechanisms relevant to dementia risk).
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\r\nThe program will combine a 1-day Scientific Symposium with internationally leading invited speakers alongside talks from the EPFL community.
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\r\nThe symposium will be followed by an early-evening roundtable intended to engage the broader campus community, including colleagues from the University of Lausanne and beyond – this roundtable will be part of the 2026 EPFL Jours Santé program.\r\n
TBD
","image_description":"","creation_date":"2026-08-06T14:16:55","last_modification_date":"2026-09-22T14:03:11","link_label":"Web Page","link_url":"https://zuckermaninstitute.columbia.edu/attila-losonczy-md-phd","canceled":"False","cancel_reason":"","place_and_room":"SV 1717","url_place_and_room":"https://plan.epfl.ch/?room==SV%201717","url_online_room":"https://epfl.zoom.us/j/64813563657","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Attila Losonczy, Columbia, US","organizer":"SV BMI Host: J. Priestley","contact":"brain_mind@epfl.ch","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/121378/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/1/?format=json","https://memento.epfl.ch/api/v1/mementos/6/?format=json","https://memento.epfl.ch/api/v1/mementos/9/?format=json","https://memento.epfl.ch/api/v1/mementos/19/?format=json","https://memento.epfl.ch/api/v1/mementos/88/?format=json"]},{"id":72369,"title":"Mechanical forces as long-range organizers of cellular physiology","slug":"mechanical-forces-as-long-range-organizers-of-cell","event_url":"https://memento.epfl.ch/event/mechanical-forces-as-long-range-organizers-of-cell","visual_url":"https://memento.epfl.ch/image/33626/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/33626/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/33626/max-size.jpg","lang":"en","start_date":"2026-10-16","end_date":"2026-10-16","start_time":"16:00:00","end_time":"16:45:00","description":"In migrating cells, the GTPase Rac organizes a protrusive front, whereas Rho organizes a contractile back, yet how these GTPases segregate remains unclear. We leverage optogenetics, mechanical perturbations, and modeling to reveal a mechanochemical long-range mutual activation between front and back polarity programs that complements their known local mutual inhibition. Rac-driven protrusions increase membrane tension, triggering mTORC2-dependent Rho activation at the opposite side of the cell. Conversely, Rho-mediated contractility induces cortical-flow regulation of phosphoinositide signaling, promoting distal Rac activation. Our findings demonstrate how the actin cortex and plasma membrane interact as an integrated mechanochemical system for long-range Rac-Rho patterning. Efficient migration also requires polarized organization of the cell interior, with organelle positioning increasingly recognized as a key determinant of cell movement. Yet how this organization is established remains unclear. Building on our mechanochemical framework, we now investigate how actin-generated forces position organelles during migration and how disruption of this intracellular organization contributes to disease.
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\r\nWebsite of the De Belly lab: https://cri.utsw.edu/faculty/henry-de-belly/
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\r\nThis is part of the Physics of Living Systems monthly symposium: https://pols.epfl.ch/physics-of-living-systems-seminars/monthly-symposium/
Lysosomes sit at the crossroads of cellular catabolism and quality control, where they must dismantle chemically diverse cargo while preserving their own integrity. I will discuss two discoveries that reveal how lysosomes solve these complementary challenges and how their failure creates disease vulnerabilities. First, I will describe Lysosomal Leucine Aminopeptidase (LyLAP), an enzyme specialized to processively degrade the hydrophobic α-helices of transmembrane proteins. LyLAP is highly expressed in pancreatic ductal adenocarcinoma, where its loss causes hydrophobic peptides to accumulate, compromises lysosomal function, and ultimately leads to cancer cell death, revealing a potential vulnerability in tumors with elevated endocytic activity. I will then describe LASER, a damage-responsive protein assembly that couples lysosomal membrane injury to repair. At its core, the oligomeric protein TFG recognizes LC3/GABARAP proteins conjugated to damaged lysosomes and recruits the ESCRT machinery to restore membrane integrity. Neurodegenerative disease-associated mutations in TFG disrupt this process, linking defective lysosomal repair to human disease. Together, these findings reveal lysosomes as dynamic systems that coordinate cargo degradation with membrane surveillance and repair to maintain cellular homeostasis.
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\r\nMore about Dr. Aakriti Jain's lab at UTSW: https://aakritijainlab.com/
Triple S (Super Sandwich Seminar) will feature three speakers per week, each giving a 15-minute presentation followed by a 5-minute Q&A session.
","image_description":"","creation_date":"2026-08-19T11:41:26","last_modification_date":"2026-08-19T14:19:10","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"SV 1717","url_place_and_room":"https://plan.epfl.ch/?room==SV%201717","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Lei Huang, Constam Lab; Nika Gorsek D'Angelo Lab; free slot","organizer":"Prof. Pierre Gönczy","contact":"Lisa Smith, ISREC Administrative Assistant","is_internal":"True","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"Super Sandwich, cancer","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/121483/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/1/?format=json","https://memento.epfl.ch/api/v1/mementos/6/?format=json","https://memento.epfl.ch/api/v1/mementos/8/?format=json","https://memento.epfl.ch/api/v1/mementos/9/?format=json","https://memento.epfl.ch/api/v1/mementos/26/?format=json"]}]}