TBD
","image_description":"","creation_date":"2026-08-06T14:16:55","last_modification_date":"2026-09-22T14:03:11","link_label":"Web Page","link_url":"https://zuckermaninstitute.columbia.edu/attila-losonczy-md-phd","canceled":"False","cancel_reason":"","place_and_room":"SV 1717","url_place_and_room":"https://plan.epfl.ch/?room==SV%201717","url_online_room":"https://epfl.zoom.us/j/64813563657","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Attila Losonczy, Columbia, US","organizer":"SV BMI Host: J. Priestley","contact":"brain_mind@epfl.ch","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/121378/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/1/?format=json","https://memento.epfl.ch/api/v1/mementos/6/?format=json","https://memento.epfl.ch/api/v1/mementos/9/?format=json","https://memento.epfl.ch/api/v1/mementos/19/?format=json","https://memento.epfl.ch/api/v1/mementos/88/?format=json"]},{"id":72622,"title":"BMI Distinguished Seminar // Gisella Vetere: From Memory Consolidation to Generalization: The Dynamic Evolution of Memory Engrams","slug":"bmi-distinguished-seminar-gisella-vetere-from-memo","event_url":"https://memento.epfl.ch/event/bmi-distinguished-seminar-gisella-vetere-from-memo","visual_url":"https://memento.epfl.ch/image/33867/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/33867/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/33867/max-size.jpg","lang":"en","start_date":"2026-10-28","end_date":"2026-10-28","start_time":"12:15:00","end_time":"13:15:00","description":"Memories are not static representations but evolve over time through consolidation and their progressive reorganization across distributed brain networks. This process allows memories to remain persistent while also becoming sufficiently flexible to guide behavior in novel situations. In this seminar, Gisella Vetere will discuss how memory engrams are reorganized from learning to remote recall and how distinct neuronal ensembles contribute to the balance between memory specificity and generalization. Combining activity-dependent neuronal tagging, circuit manipulations, and brain-wide analyses, her research seeks to uncover how memories are transformed over time and how these transformations shape adaptive—and potentially maladaptive—behavior.
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How can we meaningfully interpret neuronal calcium imaging data? Calcium imaging is one of the key methods used to record neuronal activity from the brain of animals. I will outline why the interpretation of calcium signals remains a major bottleneck in understanding neuronal activity and plasticity. I will trace the origins of this problem and how partial solutions have been provided by my own and by others' work, and how these issues are affected by recording conditions and different calcium indicators (e.g., OGB-1, GCaMP6, GCaMP8). I will propose a conceptual path forward that could make calcium imaging a more powerful tool than it currently is.
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What happens when science meets illustration, journalism, writing, and visual communication?
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\r\nJoin us for the next Biotech Chats on Science Communication, organized by BSNL (BioScience Network Lausanne), and learn what career opportunities exist beyond the lab bench!
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\r\nEvent details:\r\n
In this talk, I'll take a look at three \"microbial vignettes\". In the first, I'll examine how the presence of co-habiting microbes profoundly affects the biology of a human pathogen, Pseudomonas aeruginosa. This is important, because in diseased human airways - where P. aeruginosa is an unwelcome, but common inhabitant - the pathogen invariably shares the infection site with a variety of other microbes. It turns out that these microbial neighbours interact with one another and that these interactions are perturbed by the loss of a quorum sensing \"master regulator\" (LasR) in P. aeruginosa. In the second \"short\", I'll talk about how we are now able to manipulate the rate of evolution of the organism, either by \"stepping on the gas pedal\" or by \"slamming on the brakes\". The ability to do this, in an experimentally-controlled manner, is allowing us to access some novel evolutionary trajectories, and to address some truly fundamental biological questions. Finally, I'll take a fresh look at bacterial biofilms and in particular, examine whether the exopolysaccharide \"bioglue\" that holds these structures together might have additional - possibly more important roles. It turns out that it does, and that the exopolysaccharide matrix acts as a \"net\" to selectively sequester secreted proteins, potentially conferring novel functionalities on the biofilm.
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\r\nBrief Speaker Bio.
\r\nAfter reading for a degree in Biochemistry at the University of Oxford, Martin completed a PhD on bacterial chemotaxis at the Weizmann Institute of Science (Israel), where he was awarded the Wolf Prize for his contributions to the field. Leavuing Israel with a PhD and a [German] wife, he then moved to Toulouse (supported by a long-term EMBO fellowship) where he learned the dark art of x-ray crystallography and solved the structure of a signaling complex involved in bacterial chemotaxis. He then moved back to the UK to take up a post-doctoral position at the University of Cambridge working on quorum sensing in the fascinating plant pathogen, Pectobacterium atrosepticum. There, he developed skills in molecular genetics and demonstrated (for the first time) that quorum sensing molecules bind directly to their cognate LuxR homologs in a range of bacteria. This advance allowed him to secure a Royal Society University Research Fellowship to start his own group - where he learned the hard way that prospective students don't like any project with the word \"plant\" in, and when offered projects on the plant pathogen versus a mammalian pathogen, always went for the latter. Since around 2000, his team's focus has been on understanding better the link between metabolism and virulence in the opportunistic human pathogen, Pseudomonas aeruginosa. He is now Professor of Microbial Physiology and Metabolism at the University of Cambridge.
Title TBA
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","image_description":"","creation_date":"2026-10-01T19:35:51","last_modification_date":"2026-10-01T19:38:16","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"CH G1 495","url_place_and_room":"https://plan.epfl.ch/?room==CH%20G1%20495","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Camila Bacellar (PSI, SwissFEL) ","organizer":"Christoph Bostedt","contact":"christoph.bostedt@epfl.ch","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"pcseminar","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/122027/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/5/?format=json","https://memento.epfl.ch/api/v1/mementos/14/?format=json"]}]}