{"count":238,"next":"https://memento.epfl.ch/api/v1/events/?format=json&limit=10&offset=150&ordering=last_modification_date","previous":"https://memento.epfl.ch/api/v1/events/?format=json&limit=10&offset=130&ordering=last_modification_date","results":[{"id":71329,"title":"EPFL Spacecraft team - unveiling 2026","slug":"epfl-spacecraft-team-unveiling-2026","event_url":"https://memento.epfl.ch/event/epfl-spacecraft-team-unveiling-2026","visual_url":"https://memento.epfl.ch/image/32683/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32683/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32683/max-size.jpg","lang":"en","start_date":"2026-05-11","end_date":"2026-05-11","start_time":"18:00:00","end_time":"23:00:00","description":"<p>Come at SPOT and discover the latest advancement of the EPFL Spacecraft team association </p>","image_description":"","creation_date":"2026-03-09T10:41:28","last_modification_date":"2026-03-09T10:41:28","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"DLLEL 0 28","url_place_and_room":"https://plan.epfl.ch/?room==DLLEL%200%2028","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/1/?format=json","https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"EPFL spacecraft team association","organizer":"EPFL spacecraft team association","contact":"contact.chess@epfl.ch","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":2,"fr_label":"Sur invitation","en_label":"Invitation required"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/120015/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/398/?format=json"]},{"id":64749,"title":"BRIDGE Discovery: 10th call","slug":"bridge-discovery-10th-call","event_url":"https://memento.epfl.ch/event/bridge-discovery-10th-call","visual_url":"https://memento.epfl.ch/image/26583/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/26583/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/26583/max-size.jpg","lang":"en","start_date":"2026-04-28","end_date":"2026-04-28","start_time":null,"end_time":null,"description":"<p>BRIDGE is a joint programme conducted by the Swiss National Science Foundation (SNSF) and Innosuisse, the Swiss Innovation Agency. It offers new funding opportunities at the intersection of basic research and science-based innovation, thereby supplementing the funding activities of the two organizations.<br>\r\n<br>\r\n<strong>BRIDGE Discovery</strong> is aimed at experienced researchers who wish to realise a technological innovation with great social or economic impact. They can submit a proposal on their own or as part of a consortium of up to three applicants. The project must be characterised by scientific excellence and a clear vision of a future application.<br>\r\n<br>\r\nBRIDGE Discovery funds projects for up to 4 years. The maximum total costs must not exceed<strong> 850,000 Swiss francs per applicant over four years.</strong> Grants cover the salaries of project employees and research costs directly linked to the project.<br>\r\n<br>\r\n<strong>As of 2025, the letter of intent is no longer a prerequisite for the submission of a Discovery proposal.</strong><br>\r\n<br>\r\n<strong>Applicants must directly submit a full proposal on <a class=\"link link--size-general link--external \" href=\"https://bridge.mysnf.ch/login.aspx?returnurl=%2fdefault.aspx\" rel=\"noreferrer\" target=\"_blank\">mysnf.ch</a>.</strong><br>\r\n<br>\r\n<strong>Deadline for the submission of full proposals: 28th April 2026 (5pm Swiss time)</strong><br>\r\n<br>\r\nFurther details of the schemes, calls and requirements for the BRIDGE funding programme are available on the <a href=\"https://www.bridge.ch/en/2JhW2ZFO9e7sAImV/page/funding/discovery\">BRIDGE website</a>.<br>\r\nMore information:\r\n</p><ul>\r\n\t<li><a href=\"https://www.bridge.ch/media/en/jfEzfWt7VDjGvOEi/BRIDGE_Discovery_Regulations_en.pdf\">Regulations</a></li>\r\n\t<li><a href=\"https://www.bridge.ch/media/en/ttDfgJP5hNP6V8WC/BRIDGE_Discovery_checklist.pdf\" target=\"_blank\">Full proposal checklist</a></li>\r\n\t<li><a class=\"link link--size-general link--external \" href=\"https://www.bridge.ch/media/en/0D4F6EKRFcge6vAB/BRIDGE_Discovery_project_description_template.docx\" rel=\"noreferrer\" target=\"_blank\">Template project description (MS Word)</a></li>\r\n\t<li><a class=\"link link--size-general link--external \" href=\"https://www.bridge.ch/media/en/ZvjAhtXMjOMw1nD8/BRIDGE_Discovery_LaTeX.zip\" rel=\"noreferrer\" target=\"_blank\">Template project description (LaTeX)</a></li>\r\n\t<li><a href=\"https://drive.google.com/drive/u/0/folders/1FnJ4eaH4hyX-0fAnsmfpDo5ldYLMzks5\">ReO toolkit</a></li>\r\n</ul>\r\nFor further questions contact <a href=\"mailto:research@epfl.ch?subject=%5B%20BRIDGE%20DISCOVERY%20%E2%80%93%205th%20CALL%20%7C%20Research%20funding%20%5D\">research@epfl.ch</a>.","image_description":"","creation_date":"2023-12-15T13:37:40","last_modification_date":"2026-03-09T10:42:03","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"","url_place_and_room":"","url_online_room":"","spoken_languages":[],"speaker":"","organizer":"","contact":"research@epfl.ch","is_internal":"False","theme":"","vulgarization":{"id":1,"fr_label":"Tout public","en_label":"General public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/110291/","category":{"id":16,"code":"PROP","fr_label":"Appel à proposition","en_label":"Call for proposal","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/3/?format=json","https://memento.epfl.ch/api/v1/mementos/6/?format=json","https://memento.epfl.ch/api/v1/mementos/8/?format=json","https://memento.epfl.ch/api/v1/mementos/9/?format=json","https://memento.epfl.ch/api/v1/mementos/27/?format=json","https://memento.epfl.ch/api/v1/mementos/140/?format=json"]},{"id":71330,"title":"EPFL N-pulse - unveiling 2026","slug":"epfl-n-pulse-unveiling-2026","event_url":"https://memento.epfl.ch/event/epfl-n-pulse-unveiling-2026","visual_url":"https://memento.epfl.ch/image/32684/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32684/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32684/max-size.jpg","lang":"en","start_date":"2026-05-20","end_date":"2026-05-20","start_time":"18:00:00","end_time":"23:00:00","description":"<p>EPFL N-Pulse is a student association based in Switzerland, dedicated to developing cutting-edge, open-source biomedical technologies that are non-invasive and accessible. Come at SPOT and discover the latest developments of this MAKE project</p>","image_description":"","creation_date":"2026-03-09T10:48:30","last_modification_date":"2026-03-09T10:48:30","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"DLLEL 0 28","url_place_and_room":"https://plan.epfl.ch/?room==DLLEL%200%2028","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"EPFL N-pulse association","organizer":"EPFL N-pulse association","contact":"Roman Danylovych &lt;roman.danylovych@epfl.ch&gt;","is_internal":"False","theme":"","vulgarization":{"id":1,"fr_label":"Tout public","en_label":"General public"},"registration":{"id":2,"fr_label":"Sur invitation","en_label":"Invitation required"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/120016/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/398/?format=json"]},{"id":71324,"title":"EPFL Xplore - unveiling 2026","slug":"epfl-xplore-unveiling-2026","event_url":"https://memento.epfl.ch/event/epfl-xplore-unveiling-2026","visual_url":"https://memento.epfl.ch/image/32679/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32679/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32679/max-size.jpg","lang":"en","start_date":"2026-05-06","end_date":"2026-05-06","start_time":"18:00:00","end_time":"23:00:00","description":"<p>Come discover the new rover prototype of the EPFL Xplore team at SPOT </p>","image_description":"","creation_date":"2026-03-09T10:01:50","last_modification_date":"2026-03-09T10:51:28","link_label":"Project page","link_url":"https://make.epfl.ch/projects/2/make-epfl-xplore-2","canceled":"False","cancel_reason":"","place_and_room":"DLLEL 0 28","url_place_and_room":"https://plan.epfl.ch/?room==DLLEL%200%2028","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Management of EPFL Xplore association, EPFL Space Center","organizer":"EPFL Xplore association","contact":"contact@epfl-xplore.ch","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":2,"fr_label":"Sur invitation","en_label":"Invitation required"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/120008/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/10/?format=json","https://memento.epfl.ch/api/v1/mementos/398/?format=json"]},{"id":71120,"title":"IMX Colloquium - Domain walls in multiferroics and multiferroic domain walls","slug":"imx-colloquium-domain-walls-in-multiferroics-and-2","event_url":"https://memento.epfl.ch/event/imx-colloquium-domain-walls-in-multiferroics-and-2","visual_url":"https://memento.epfl.ch/image/32492/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32492/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32492/max-size.jpg","lang":"en","start_date":"2026-04-20","end_date":"2026-04-20","start_time":"13:15:00","end_time":"14:15:00","description":"<p>A reason for the interest in multiferroics is that magnetic and electric orders do not simply exist side by side, but exhibit \"added value\" in the form of magnetoelectric interactions and functionalities between the ordered states. Likewise, in a ferroic material, regions with different orientation of the order parameter, the domains, do not simply exist side by side, but they exhibit new phases and properties in the domain walls. Because of their discontinuous, confined, and topological nature, domain walls exhibit functional states that are not possible in the bulk. Continuing this line of thought, one should expect domain walls in multiferroics to be a particularly rich source of novel phenomena. Here one must distinguish between (i) \"domain walls in multiferroics\", where only the ferroelectric (or magnetic) order is considered so that little is learned about the multiferroic state, and (ii) \"multiferroic domain walls\" where the ferroic phase coexistence of the wall itself is of interest. The latter are rarely studied, and I will discuss some of their intriguing features in my talk.<br>\r\n<br>\r\nBio: Professor Manfred Fiebig is known for his work in light-matter interaction in systems with strong electronic correlations. (Multi-) ferroics are of particular interest to him. After obtaining his doctoral degree in physics at the University of Dortmund, he worked at the University of Tokyo, the Max Born Institut Berlin, and the University of Bonn before he was appointed as Professor of Multifunctional Ferroic Materials in the Department of Materials at ETH Zurich in 2011. In 2021 he also became a member of the National Research Council of the Swiss National Science Foundation (SNSF), and he was elected as Corresponding Member of the Academy of Sciences and Literature | Mainz. Most recent distinctions include the 2022 APS Frank Isakson Prize for Optical Effects in Solids as well as the of the Stern Gerlach Medal in 2023, the highest distinction in Experimental Physics of the German Physical Society. He is one of the founders of the ETH Spinoff Company “3Wave Instruments”.</p>","image_description":"","creation_date":"2026-02-12T08:41:37","last_modification_date":"2026-03-09T10:58:25","link_label":"Website","link_url":"https://mat.ethz.ch/department/people/person-detail.fiebig.html","canceled":"False","cancel_reason":"","place_and_room":"MXF 1","url_place_and_room":"https://plan.epfl.ch/?room==MXF%201","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Prof. Manfred Fiebig, ETHZ","organizer":"Prof. Gregor Jotzu, Prof. Fabien Sorin &amp; Prof. Esther Amstad","contact":"Prof. Gregor Jotzu, Prof. Fabien Sorin &amp; Prof. Esther Amstad","is_internal":"False","theme":"","vulgarization":{"id":1,"fr_label":"Tout public","en_label":"General public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/119701/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/8/?format=json","https://memento.epfl.ch/api/v1/mementos/314/?format=json"]},{"id":71326,"title":"Camp Océan - Sailowtech","slug":"camp-ocean-sailowtech","event_url":"https://memento.epfl.ch/event/camp-ocean-sailowtech","visual_url":"https://memento.epfl.ch/image/32680/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32680/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32680/max-size.jpg","lang":"en","start_date":"2026-04-25","end_date":"2026-04-25","start_time":"13:30:00","end_time":"15:30:00","description":"<p>This event is free and open to everyone. It aims to raise awareness of various issues concerning the ocean through workshops, exhibitions, conferences, and a roundtable discussion. The day will end with a convivial gathering over drinks and appetizers.</p>","image_description":"","creation_date":"2026-03-09T10:11:14","last_modification_date":"2026-03-09T11:01:26","link_label":"Register here","link_url":"https://infomaniak.events/fr-ch/conferences/camp-ocean-locean-de-demain-organise-par-sailowtech/77c17e0d-d9cf-46c8-bc8f-066c2ca7e639/events/386558","canceled":"False","cancel_reason":"","place_and_room":"DLLEL 0 28","url_place_and_room":"https://plan.epfl.ch/?room==DLLEL%200%2028","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/1/?format=json"],"speaker":"Sailowtech (EPFL association) - Jérome Chappellaz (EPFL, Laboratoire SENSE) - Lucas Paoli (EPFL, Laboratoire Microbiome Immunity and Ecology) - Anders Meibom (EPFL, Laboratory for Biological Geochemistry) - Lili Lesimple (Geneva Ocean Academy)","organizer":"Sailowtech association","contact":"contact@sailowtech.ch","is_internal":"False","theme":"","vulgarization":{"id":1,"fr_label":"Tout public","en_label":"General public"},"registration":{"id":1,"fr_label":"Sur inscription","en_label":"Registration required"},"keywords":"sustainability, marine conservation","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/120011/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/10/?format=json","https://memento.epfl.ch/api/v1/mementos/398/?format=json","https://memento.epfl.ch/api/v1/mementos/79/?format=json"]},{"id":71337,"title":"Brown Bag Seminar in Finance","slug":"brown-bag-seminar-in-finance-6","event_url":"https://memento.epfl.ch/event/brown-bag-seminar-in-finance-6","visual_url":"https://memento.epfl.ch/image/32691/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32691/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32691/max-size.jpg","lang":"en","start_date":"2026-06-23","end_date":"2026-06-23","start_time":"12:15:00","end_time":"13:15:00","description":"","image_description":"","creation_date":"2026-03-09T16:38:27","last_modification_date":"2026-03-09T16:38:27","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"UNIL, Extranef, room 126","url_place_and_room":"","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Darius Nik Nejad - SFI@EPFL PhD student  ","organizer":"","contact":"sophie.cadenakauz@epfl.ch","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/120027/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/3/?format=json","https://memento.epfl.ch/api/v1/mementos/116/?format=json","https://memento.epfl.ch/api/v1/mementos/39/?format=json","https://memento.epfl.ch/api/v1/mementos/105/?format=json"]},{"id":71338,"title":"Probing Ultrafast Electron Motion with Attosecond X-ray Free Electron Lasers","slug":"probing-ultrafast-electron-motion-with-attosecond","event_url":"https://memento.epfl.ch/event/probing-ultrafast-electron-motion-with-attosecond","visual_url":"https://memento.epfl.ch/image/32692/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32692/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32692/max-size.jpg","lang":"en","start_date":"2026-04-23","end_date":"2026-04-23","start_time":"17:15:00","end_time":"18:30:00","description":"<p>The ultrafast motion of electrons is a frontier problem for photochemical processes, as electron motion is a key ingredient of all chemical reactions. Electronic rearrangement is also the means by which light energy is harnessed in photochemistry. The timescale for coherent electron dynamics is set by the energetic splitting of the electronic states, which in small molecular systems, is on the scale of an electron volt (eV). This sets the natural timescale for electronic motion to be few-to-sub femtosecond (fs).<br>\r\n<br>\r\nTo approach these extreme timescales, we can use short pulses of light to excite small quantum systems. For instance, the impulsive interactions between a light field and a quantum system can induce time-dependent oscillations in the charge density. Such electronic wavepacket motion (in the absence of nuclear motion) has come to be referred to as charge migration [1]. While the initial charge dynamics following impulsive excitation (or ionization) begins as purely electronic motion, this wavepacket will couple to other degrees of freedom in the system (i.e. nuclear motion or chemical dynamics) and lead to localization of the charge.  The transfer of electronic charge across molecular bonds is fundamental to an understanding of charge transfer phenomena.<br>\r\n<br>\r\nThe study of these fundamental phenomena requires state-of-the-art light sources, such as the Linac Coherent Light Source (LCLS), an X-ray free electron laser (XFEL) facility which produces high-brightness, ultrashort pulses, with wavelength continuously tunable across the x-ray regime. Schemes to provide isolated, sub-femtosecond pulses from an FEL are being explored at facilities world-wide, and recently we have demonstrated such pulses at the LCLS [2]; opening the door for time-resolved measurements of ultrafast electron dynamics on their natural timescale. In my talk, I will highlight our recent developments in probing electronic motion in small molecular systems. We have employed sub-femtosecond pulses from the XFEL to study ultrafast charge dynamics in both core-excited [3,4,5] and low-lying cationic systems [6]. We are also developing nonlinear x-ray spectroscopies [7,8] to initiate and control electron dynamics. The control of coherent electron motion represents a significant step towards achieving charge-directed reactivity [9], a grand challenge for the field of attosecond science.<br>\r\n<br>\r\n[1] Cederbaum and Zobeley 1999 Chemical Physics Letters 307 205–210<br>\r\n[2] Duris and Li et al. 2020 Nature Photonics 14 30-36<br>\r\n[3] Li and Driver et al. 2022 Science 375 285-290<br>\r\n[4] Driver et al. 2024 Nature 632 762-767 (2024)<br>\r\n[5] Wang and Driver et al. Phys. Rev. X 15 011008 (2005)<br>\r\n[6] Driver et al. ArXiv:2411.01700<br>\r\n[7] O’Neal et al. 2020 Phys. Rev. Lett. 125 073203<br>\r\n[8] Biggs et al. 2023 Proc. Nat. Acad. Sci. 110 15597-15601<br>\r\n[9] F. Remacle, R. D. Levine, and M. A. Ratner 1998 Chem. Phys. Lett. 285, 25<br>\r\n </p>","image_description":"","creation_date":"2026-03-10T09:08:13","last_modification_date":"2026-03-10T09:08:45","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"CH G1 495","url_place_and_room":"https://plan.epfl.ch/?room==CH%20G1%20495","url_online_room":"https://epfl.zoom.us/j/67570484652?pwd=UpB6UFTCS3n1QpxlIaYM2UvuMD3tkr.1","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"James Cryan, Stanford Univ. / SLAC","organizer":"Christoph Bostedt","contact":"Christoph Bostedt","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"pcseminar","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/120028/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/1/?format=json","https://memento.epfl.ch/api/v1/mementos/5/?format=json","https://memento.epfl.ch/api/v1/mementos/204/?format=json","https://memento.epfl.ch/api/v1/mementos/14/?format=json","https://memento.epfl.ch/api/v1/mementos/191/?format=json","https://memento.epfl.ch/api/v1/mementos/6/?format=json"]},{"id":70935,"title":"Genome-wide in vitro reconstitution to study nucleosome positioning and chromatin architecture","slug":"genome-wide-in-vitro-reconstitution-to-study-nucle","event_url":"https://memento.epfl.ch/event/genome-wide-in-vitro-reconstitution-to-study-nucle","visual_url":"https://memento.epfl.ch/image/32323/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32323/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32323/max-size.jpg","lang":"en","start_date":"2026-05-20","end_date":"2026-05-20","start_time":"17:00:00","end_time":"18:30:00","description":"<p>Access to genetic information within the cell nucleus is regulated by the distribution of nucleosomes, which are the basic unit of chromatin. Local access to specific genomic regions is facilitated by repositioning nucleosomes to enable transcription and other nuclear processes. Nucleosome positioning is primarily regulated by ATP-dependent chromatin remodeling enzymes (CRs) that belong to the Snf2-type helicase family. These enzymes disrupt histone-DNA contacts by consuming ATP. The functions of CRs can be redundant or essential, complicating their study in vivo. To address this, we employ a unique bottom-up approach, in which we reconstitute chromatin in vitro using purified proteins and a yeast genomic plasmid library. To elucidate the diverse remodeling functions of CRs, we add purified CRs in combination with various transcription factors to the in vitro reconstituted chromatin. The resulting changes in nucleosome positioning are monitored using MNase-seq. Depending on the type of CR used, we observe distinct nucleosome positioning patterns. Furthermore, we have expanded our in vitro reconstitution approach to explore the 3D genome organization of reconstituted chromatin, discovering a role for CRs in the 3D genome organization of <em>S. cerevisiae</em>.</p>","image_description":"","creation_date":"2026-01-23T09:41:37","last_modification_date":"2026-03-10T12:18:20","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"BCH 2218","url_place_and_room":"https://plan.epfl.ch/?room==BCH%202218","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"<a href=\"https://www.uni-goettingen.de/en/689675.html\">Elisa Oberbeckmann</a> (University of Goettingen)","organizer":"Professeur Beat Fierz","contact":"Marie Munoz","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"CBseminar","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/119413/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/1/?format=json","https://memento.epfl.ch/api/v1/mementos/14/?format=json","https://memento.epfl.ch/api/v1/mementos/6/?format=json"]},{"id":70936,"title":"Probing and Modulating Transcription Factor–DNA Interactions via Chemically Modified Proteins","slug":"probing-and-modulating-transcription-factordna-i-2","event_url":"https://memento.epfl.ch/event/probing-and-modulating-transcription-factordna-i-2","visual_url":"https://memento.epfl.ch/image/32324/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/32324/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/32324/max-size.jpg","lang":"en","start_date":"2026-05-19","end_date":"2026-05-19","start_time":"16:15:00","end_time":"17:45:00","description":"<p>Chemical protein synthesis provides a powerful means to prepare novel, modified proteins with atomic-level precision, offering unprecedented opportunities to understand fundamental biological processes.<sup>1</sup> Of particular interest is gene expression, which is controlled through interactions between transcription factors (TFs) and DNA. This presentation will highlight the power of combining total synthesis and late-stage transformations to generate complex, modified proteins for deciphering the molecular roles of post-translational modifications (PTMs) in TFs regulation. Specific examples will focus on the synthesis of site-specifically phosphorylated and acetylated TFs, such as the Myc/Max system.<sup>2, 3</sup> Remarkably, these studies revealed that phosphorylation and acetylation patterns modulate Max–DNA interactions by altering DNA binding affinity and sequence specificity. Importantly, such mechanistic insights led to the development of novel bioactive miniproteins derived from Max (μMax), capable of inhibiting oncogene expression and cancer cell proliferation through antagonistic binding to target genes in cancer cells, paving the way for the development of new therapeutic proteins targeting oncogene expression.<sup>4-6</sup><br>\r\n<br>\r\n<br>\r\n1. O. Harel, M. Jbara, <em>Angew. Chem. Int. Ed., </em><strong>2023</strong>, <em>62</em>, e202217716<br>\r\n2. R. Nithun, Y. Yao, X. Lin, S. Habiballah, A. Afek, M. Jbara, <em>Angew. Chem. In. Ed., </em><strong>2023</strong>,<em> 62,</em> e202310913<br>\r\n3. R. Nithun, Y. Yao, O. Harel, S. Habiballah, A. Afek, M. Jbara, <em>ACS Central Science, </em><strong>2024</strong>, <em>10</em>, 1295–1303<br>\r\n4. X. Lin, S. Mandal, R. Nithun, R. Kolla, B. Bouri, H. Lashuel, M. Jbara, <em>JACS</em>, <strong>2024</strong>, 146, 25788<br>\r\n5. X. Lin, O. Harel, M. Jbara, <em>Angew. Chem. In. Ed.,</em> <strong>2024</strong>, <em>63,</em> e202317511<br>\r\n6. O. Harel, F. Nadal-Bufi, R. Nithun, Y. Yao, A. Afek, M. Vendrell, M. Jbara, <em>JACS</em>, <strong>2025</strong>, 147, 46, 42647</p>","image_description":"","creation_date":"2026-01-23T10:10:50","last_modification_date":"2026-03-10T12:19:13","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"BCH 2218","url_place_and_room":"https://plan.epfl.ch/?room==BCH%202218","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"<a href=\"https://www.jbaralab.sites.tau.ac.il/mj\">Dr Muhammad Jbara</a> (Tel Aviv University)","organizer":"Professor Fierz Beat","contact":"Marie Munoz","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"CBseminar","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/119416/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/14/?format=json"]}]}