Thesis Director: Prof. V. Panaretos,
\r\nMathematics doctoral program
\r\nThesis Nr. 11953
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\r\nTo take part in the public defense, please contact directly the speaker
Weekly BioEngineering Talks (Lunch Provided)
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\r\nINVITED SPEAKERS:
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\r\nOrganic electrochemical transistors for enhanced potentiometric sensing of neurochemicals
\r\nDr. Emily Schafer, EPFL Laboratory of Chemical Nanotechnology
\r\nHost: Prof. Nako Nakatsuka
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\r\nFollowed by
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\r\nData-driven protein engineering for sensing and biosynthesis of new-to-nature thioesters
\r\nDr. Sebastian Barthel, EPFL Laboratory of Synthetic and Applied Microbiology
\r\nHost: Prof. Markus Jeschek
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\r\nBioEngineering Talks mandatory EDBB Seminar Attendance (1st-Year PhD Students)\r\n
Weekly BioEngineering Talks ( Lunch Provided)
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\r\nINVITED SPEAKER:
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\r\nA full-stack viral toolkit for systems neuroscience
\r\nProf. Lief Fenno, University of Texas at Austin
\r\nHost: Prof. Yoon Seok Kim
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\r\nAbstract:
\r\n Understanding and manipulating neural circuits requires technologies enabling access to specific cells, manipulation of genome structure, and delivery of increasingly complex genetic programs. I will describe viral technologies developed by my group that address each of these challenges. These include INTRSECT, a Boolean viral targeting strategy for cell-type- and circuit-specific access; VESPA, a novel split-AAV platform that enables efficient reassembly and expression of genetic payloads too large for a single AAV; and CRISPR/Cas9-based strategies for precise, cell-type- and circuit-specific gene knockdown. Together, these tools form an integrated viral toolkit for programmable access to and manipulation of neural circuits across multiple levels of biological complexity.
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\r\nBio:
\r\nDr. Lief Fenno is a physician-scientist at The University of Texas at Austin and Dell Medical School. His research integrates systems neuroscience, synthetic biology, and bioengineering to develop genetic, viral, and neuromodulation technologies for programmable control of neural circuits in vivo. His laboratory develops molecular and viral platforms for selectively accessing and manipulating defined neural populations, alongside approaches for neural stimulation and emerging therapeutic applications. His work spans fundamental circuit neuroscience, neurotechnology, and the translation of biological tools to treatment of brain disorders. Dr. Fenno is also a board-certified addiction psychiatrist, Chair of the American Psychiatric Association Council on Addiction Psychiatry, and is active in commercial scientific translation and biotechnology innovation.
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\r\nBioEngineering Talks mandatory EDBB Seminar Attendance (1st-Year PhD Students)\r\n
Multi-robot systems are physically embodied networks — they sense, move, and communicate through the physical world. The bar for safe decision-making rises as these systems enter safety-critical, real-world settings where they must perform well under uncertainty. Our work shows that physicality is a resource against the two kinds of uncertainty they face: intentional (or adversarial), where data is manipulated by malicious agents, and natural, where aspects of the environment are simply unknown. Most of this talk concerns intentional uncertainty. Here, one way to exploit physicality is by using communication as a sensor. Because the signals robots exchange are difficult to forge, they carry evidence that can be cross-validated to yield a quantifiable likelihood that an agent's data is trustworthy. This is the foundation of cy-trust, in which stochastic observations of trust model an agent's trustworthiness probabilistically from physical rather than cryptographic evidence. Each neighbor's contribution is then weighted by its trust value. Under this framework, we show that consensus, distributed optimization, and other core coordination tasks admit almost-sure convergence with bounded deviation from their nominal performance, even when malicious agents exceed half of a node's connectivity, past the classical Byzantine bound. We support this finding with both theory and hardware experiments under adversarial attack. Against natural uncertainty, we show that real-time sensing can be folded into rollout-based reinforcement learning, where the same machinery reweights futures rather than neighbors. We apply this idea to routing a fleet of robots to stochastically appearing demand and, with Project CETI, to the first autonomous robotic rendezvous with sperm whales at sea. Finally, we preview some of our future work combining trust with long-horizon sequential decision-making, targeting planning that stays provably resilient when the data informing the plan may itself be corrupted.
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\r\nStephanie Gil is the John L. Loeb Associate Professor of Engineering and Applied Sciences at Harvard University and an Associate Faculty member of the Kempner Institute. Her research focuses on trust and coordination in multi-robot systems, at the intersection of robotics, communication, and learning. Her contributions have been recognized through the DARPA Young Faculty Award (2024), the Office of Naval Research Young Investigator Award (2021), and the National Science Foundation CAREER Award (2019). She was named a 2020 Sloan Research Fellow for her work at the intersection of robotics and communication. She earned her Ph.D. at CSAIL at MIT, specializing in multi-robot coordination and control, and her B.S. at Cornell University.
Thesis Director: Prof. N. Marzari,
\r\nMaterials Science and Engineering doctoral program
\r\nThesis Nr. 11813
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\r\nTo take part in the public defense, please contact directly the speaker