Thesis Director: Prof. P. D. Barth,
\r\nBiotechnology and Bioengineering doctoral program
\r\nThesis Nr. 11393
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\r\nTo take part in the public defense, please contact directly the speaker
In this seminar, I will discuss our efforts to design conformationally constrained helical macrocyclic peptides and outline the principles that enable effective targeting of protein–protein interactions beyond classical stapled peptides. In the second part, I will show how a subtle isosteric backbone modification—thioamidation—can be used to impart oral bioavailability to bioactive macrocyclic peptides. I will further illustrate how conformational restriction enhances membrane permeability and highlight the critical role of metabolic stability in achieving oral bioavailability.
","image_description":"Prof. Jayanta Chatterjee","creation_date":"2026-03-30T19:14:23","last_modification_date":"2026-03-30T19:24:00","link_label":"Publications Prof. Jayanta Chatterjee","link_url":"https://scholar.google.com/citations?user=r0aQPNIAAAAJ&hl=en","canceled":"False","cancel_reason":"","place_and_room":"BCH 3118","url_place_and_room":"https://plan.epfl.ch/?room==BCH%203118","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Prof. Jayanta Chatterjee, Indian Institute of Science, Bangalore, India","organizer":"C. Heinis","contact":"C. Heinis","is_internal":"False","theme":"","vulgarization":{"id":2,"fr_label":"Public averti","en_label":"Informed public"},"registration":{"id":3,"fr_label":"Entrée libre","en_label":"Free"},"keywords":"cbseminar","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/120241/","category":{"id":1,"code":"CONF","fr_label":"Conférences - Séminaires","en_label":"Conferences - Seminars","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/9/?format=json","https://memento.epfl.ch/api/v1/mementos/5/?format=json","https://memento.epfl.ch/api/v1/mementos/14/?format=json"]},{"id":71507,"title":"Genome-wide mapping of Transcription Factors' Footprints: Probing Noncoding Variants of Human Diseases","slug":"genome-wide-mapping-of-transcription-factors-footp","event_url":"https://memento.epfl.ch/event/genome-wide-mapping-of-transcription-factors-footp","visual_url":null,"visual_large_url":null,"visual_maxsize_url":null,"lang":"en","start_date":"2026-05-08","end_date":"2026-05-08","start_time":"15:00:00","end_time":"16:00:00","description":"","image_description":"","creation_date":"2026-03-31T15:22:33","last_modification_date":"2026-03-31T15:22:33","link_label":"","link_url":"","canceled":"False","cancel_reason":"","place_and_room":"SV 1717","url_place_and_room":"https://plan.epfl.ch/?room==SV%201717","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/2/?format=json"],"speaker":"Professor Xiaoliang Sunney XieThesis Director: Prof. H. Altug,
\r\nBiotechnology and Bioengineering doctoral program
\r\nThesis Nr. 11156
\r\n
\r\nTo take part in the public defense, please contact directly the speaker
Join us for a community event presenting the first outcomes of the review phase of the s’EPanouir-FLourish initiative that will take place on Monday 27th of April from 13h30-15h30. The event can also be followed online.
\r\nSince room capacity is limited, attendance on site will be first-come first-served. For logistical reasons, we kindly ask you to signal your intention to attend (on site or online) via the following link: https://forms.cloud.microsoft/e/gMCxd941Lp
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\r\nDuring this event, Nicolas Grandjean, Associate Vice President for Education (AVPE), and the chairs of the Working Groups will present the main points of the Draft Feasibility Report, which is now open for feedback from teachers, sections and students.
\r\nThe session will consist of short 5‑minute presentations for each topic, followed by time for Q&A and brief small‑group discussions. Participants will also be able to share individual feedback via an online form.
\r\nThe report can be accessed online with your EPFL e-mail.
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\r\nAgenda:
\r\n13h30 – Opening remarks
\r\n13h35 – Basic educational goals and design features (Chapter 1)
\r\n14h00 – Bachelor program: thinking deeply and engaging with complexity (Chapter 2)
\r\n14h25 – Mastery and depth in first-year core disciplines (Chapter 3)
\r\n14h50 – Resources and support (Chapters 4 and 5)
\r\n15h15 – Next steps
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\r\nWe look forward to seeing you there!
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