How can we meaningfully interpret neuronal calcium imaging data? Calcium imaging is one of the key methods used to record neuronal activity from the brain of animals. I will outline why the interpretation of calcium signals remains a major bottleneck in understanding neuronal activity and plasticity. I will trace the origins of this problem and how partial solutions have been provided by my own and by others' work, and how these issues are affected by recording conditions and different calcium indicators (e.g., OGB-1, GCaMP6, GCaMP8). I will propose a conceptual path forward that could make calcium imaging a more powerful tool than it currently is.
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Memories are not static representations but evolve over time through consolidation and their progressive reorganization across distributed brain networks. This process allows memories to remain persistent while also becoming sufficiently flexible to guide behavior in novel situations. In this seminar, Gisella Vetere will discuss how memory engrams are reorganized from learning to remote recall and how distinct neuronal ensembles contribute to the balance between memory specificity and generalization. Combining activity-dependent neuronal tagging, circuit manipulations, and brain-wide analyses, her research seeks to uncover how memories are transformed over time and how these transformations shape adaptive—and potentially maladaptive—behavior.
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TBD
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\r\nJoin us for the next Biotech Chats on Science Communication, organized by BSNL (BioScience Network Lausanne), and learn what career opportunities exist beyond the lab bench!
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\r\nEvent details:\r\n