Macrocyclic peptides are promising molecules for targeting intracellular protein–protein interactions and other challenging biological targets. However, their poor membrane permeability often limits their biological and therapeutic applications. Understanding the structural factors that govern passive membrane permeation is therefore essential for the rational design of cell-permeable macrocyclic peptides.
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\r\nIn this seminar, I will present our recent efforts to understand and predict the membrane permeability of macrocyclic peptides using large-scale experimental data, conformational analysis, and machine learning. We aim to clarify how conformational flexibility, including molecular chameleonicity, influences membrane permeability.
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\r\nI will also introduce our ongoing efforts toward DNA-encoded macrocyclic N-methyl peptide libraries as a future platform for discovering functional intracellular binders.
From the earliest dreams of travel imagined in literature to space missions shaping scientific research today, the Moon remains a horizon that is at once scientific, historical, and symbolic.
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\r\nOn the occasion of the Artemis II mission, the Library highlights its collections dedicated to the Moon and to space exploration: Astronauts’ memoirs, scientific works, NASA archives, and works of fiction. Explore the many ways in which the Moon and the Universe have been imagined, studied, and told.
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\r\nAll the documents on display are available to borrow under usual conditions.
You can apply to participate and find all the relevant information (speakers, abstracts, program,...) on the event website: https://www.cecam.org/workshop-details/multi-scale-and-multi-purpose-simulations-of-dna-the-importance-of-data-1484.
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\r\nRegistration is required to attend the full event, take part in the social activities and present a poster at the poster session (if any). However, the EPFL community is welcome to attend specific lectures without registration if the topic is of interest to their research. Do not hesitate to contact the CECAM Event Manager if you have any question.
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\r\nDescription
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\r\nDNA is a dramatic example of a multiscale system, where Å-scale details impact the global properties of a meter-long fiber and where femtosecond processes can impact on the entire genome years later. This implies that any theoretical study on DNA should take into consideration the vast variety of space and time scales, making it necessary the adoption of multi-physics approaches, covering the entire range of theoretical methods from quantum chemistry to rough mesoscopic models. Within this scenario the importance of data to bias simulations and as a reference to calibrate low resolution methods (Dans et al. 2017; Neguembor et al. 2022; Schultz et al. 2025).
\r\nLarge efforts have been made to develop accurate low level DFT and semiempirical methods that can be data-providers for a new generation of force-field, as well as integrated in QM/MM packages for an efficient representation of DNA reactivity (Aranda et al. 2019). Atomistic force-field have gained accuracy, showing good ability to reproduce unusual forms of DNA and long segments of DNA in the context of chromatin (Collepardo-Guevara et al. 2015; Genna et al. 2025) and providing very useful data for the calibration of lower level coarse-grained or mesoscopic methods(De Pablo 2011; Farré-Gil et al. 2024) ,which have gained sequence specificity, scalability and computational efficiency, allowing to simulate kilo-to-megabase fragments of DNA. Very remarkable efforts have been made to move up these methods to represent chromatin, which requires the introduction of biases derived from experimental data (MNAseq, chromosome conformation capture, and even static or dynamic pictures obtained by ultra-resolution microscopy, and others (Buitrago et al. 2019; Neguembor et al. 2022; Li and Schlick 2024)). This has opened the possibility to recover dynamic “base-pair” resolution pictures of chromatin and study aspects from local and global chromatin rearrangements to inter-play between effector proteins and nucleosomes, the impact of lesions in chromatin structure, and even the role of phase separation in defining local chromatin arrangements (Joseph et al. 2021; Liu et al. 2025; Park et al. 2025).
\r\nAs the target systems move from the small atomistic detail to the entire chromatin fiber, the community is broken into different sub-communities. This generates a risk of disconnection, which would lead to a waste of effort reformulating solutions to already solved problems, or ignoring the characteristic that a method should have to maintain coherence with more accurate models, or to scale to represent systems of real biological interest. This will be the main objective of this meeting, which will join a variety of sub-communities with a common interest: the DNA.
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\r\nReferences
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\r\n[1] J. Aranda, M. Terrazas, H. Gómez, N. Villegas, M. Orozco, Nat. Catal., 2, 544-552 (2019)
\r\n[2] D. Buitrago, L. Codó, R. Illa, P. de Jorge, F. Battistini, O. Flores, G. Bayarri, R. Royo, M. Del Pino, S. Heath, A. Hospital, J. Gelpí, I. Heath, M. Orozco, Nucleic Acids Research, 47, 9511-9523 (2019)
\r\n[3] R. Collepardo-Guevara, G. Portella, M. Vendruscolo, D. Frenkel, T. Schlick, M. Orozco, J. Am. Chem. Soc., 137, 10205-10215 (2015)
\r\n[4] P. Dans, I. Ivani, A. Hospital, G. Portella, C. González, M. Orozco, Nucleic. Acids. Res., gkw1355 (2017)
\r\n[5] J. de Pablo, Annu. Rev. Phys. Chem., 62, 555-574 (2011)
\r\n[6] D. Farré-Gil, J. Arcon, C. Laughton, M. Orozco, Nucleic Acids Research, 52, 6791-6801 (2024)
\r\n[7] V. Genna, G. Portella, A. Sala, M. Terrazas, I. Serrano-Chacón, J. González, N. Villegas, L. Mateo, C. Castellazzi, M. Labrador, A. Aviño, A. Hospital, A. Gandioso, P. Aloy, I. Brun-Heath, C. Gonzalez, R. Eritja, M. Orozco, Nucleic Acids Research, 53, (2025)
\r\n[8] J. Joseph, A. Reinhardt, A. Aguirre, P. Chew, K. Russell, J. Espinosa, A. Garaizar, R. Collepardo-Guevara, Nat. Comput. Sci., 1, 732-743 (2021)
\r\n[9] Z. Li, T. Schlick, Nucleic Acids Research, 52, 583-599 (2023)
\r\n[10] S. Liu, C. Wang, B. Zhang, Biochemistry, 64, 1750-1761 (2025)
\r\n[11] M. Neguembor, J. Arcon, D. Buitrago, R. Lema, J. Walther, X. Garate, L. Martin, P. Romero, J. AlHaj Abed, M. Gut, J. Blanc, M. Lakadamyali, C. Wu, I. Brun Heath, M. Orozco, P. Dans, M. Cosma, Nat. Struct. Mol. Biol., 29, 1011-1023 (2022)
\r\n[12] S. Park, R. Merino-Urteaga, V. Karwacki-Neisius, G. Carrizo, A. Athreya, A. Marin-Gonzalez, N. Benning, J. Park, M. Mitchener, N. Bhanu, B. Garcia, B. Zhang, T. Muir, E. Pearce, T. Ha, Nature, (2025)
\r\n[13] E. Schultz, J. Kaplan, Y. Wu, S. Kyhl, R. Willett, J. de Pablo, WIREs. Comput. Mol. Sci., 15, (2025)
This summer school, organized by seven PhD students from EPFL and ETH Zurich, brings together leading researchers and postgraduate students. Participants will learn modern mathematical and probabilistic methods for linear algebra through lectures by experts in randomized numerical linear algebra. The program also includes networking opportunities with fellow participants, lecturers, and industry representatives.
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\r\nThe summer school takes place in a modern hotel in the middle of the historic lakeside town of Murten/Morat. Accommodation, food, and all other costs during the summer school will be covered. All participants are charged a small registration fee.
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\r\nRegistrations can be made until February 15 and are primarily open to doctoral students from the ETH domain, with limited exceptions for international and master’s students. It is possible to obtain 2 ECTS credits for attending MoRAT.
Conflicts are part of daily life and commonly arise in a business environment. Poorly managed, or not properly resolved, they can cause significant harm, both on an interpersonal level and for the organisation itself. Productivity may be affected and finances impacted as a result of tensions between colleagues.
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\r\nDifferent approaches to conflict management are increasingly being used, helping clarify messy situations, lessening the tensions and enabling employees to continue to work together.
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\r\nThis seminar presents several separate yet related methods of conflict management. One of which, mediation, enables the parties in dispute to work towards a viable solution by taking into account all the different aspects of the problem. The mediator, as a neutral third party, uses tools and communication skills to help the parties elaborate, themselves, mutually satisfactory solutions. Participants will learn skills that will enable them to understand conflict and to manage, and ultimately resolve, disputes.
Prendre sa retraite après un long parcours professionnel ne va pas forcément de soi, si l'on pense à la place prise par le travail dans son parcours de vie. Le séminaire a pour objectif d'aider les participant.e.s à identifier les changement que cette transition introduira dans leur existence, afin d'anticiper et construire un nouvel équilibre de vie. Il s'agit également de conscientiser tous les aspects de cette période de la vie et les adaptations à réaliser, seul.e ou en couple, ainsi qui de définir les axes principaux et futures activités et projets. Les questions liées aux aspects financiers et au maintien de son capital santé, sont aussi abordées.
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","image_description":"","creation_date":"2025-11-11T16:07:20","last_modification_date":"2025-11-17T12:53:37","link_label":"Inscription","link_url":"https://epfl.eu.crossknowledge.com/site/m/public_training/705","canceled":"False","cancel_reason":"","place_and_room":"","url_place_and_room":"","url_online_room":"","spoken_languages":["https://memento.epfl.ch/api/v1/spoken_languages/1/?format=json"],"speaker":"AvantAge","organizer":"KeepLearning","contact":"keeplearning@epfl.ch","is_internal":"True","theme":"","vulgarization":{"id":1,"fr_label":"Tout public","en_label":"General public"},"registration":{"id":1,"fr_label":"Sur inscription","en_label":"Registration required"},"keywords":"","file":null,"icalendar_url":"https://memento.epfl.ch/event/export/118551/","category":{"id":15,"code":"FORM","fr_label":"Formations internes","en_label":"Internal trainings","activated":true},"academic_calendar_category":null,"domains":[],"mementos":["https://memento.epfl.ch/api/v1/mementos/6/?format=json","https://memento.epfl.ch/api/v1/mementos/145/?format=json","https://memento.epfl.ch/api/v1/mementos/431/?format=json"]},{"id":70392,"title":"Self-Leadership","slug":"self-leadership-9","event_url":"https://memento.epfl.ch/event/self-leadership-9","visual_url":"https://memento.epfl.ch/image/31851/200x112.jpg","visual_large_url":"https://memento.epfl.ch/image/31851/720x405.jpg","visual_maxsize_url":"https://memento.epfl.ch/image/31851/max-size.jpg","lang":"en","start_date":"2026-06-17","end_date":"2026-06-19","start_time":"09:00:00","end_time":"17:30:00","description":"Le self-leadership est un processus qui permet à une personne d’être plus à l’aise avec qui elle est, et qui l’amène à développer son potentiel et à construire une fondation solide à partir de laquelle toute décision – tant au niveau professionnel que personnel – peut être prise sereinement. Un bon niveau de self-leadership permet de s’épanouir à la fois dans sa propre personnalité et dans ses relations avec les autres, d’atteindre ses objectifs, et finalement, d’être un meilleur leader pour les autres.
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\r\nComment cet atelier peut vous aider: Les 3 piliers du self-leadership seront approfondis : la conscience de soi, la confiance en soi et la gestion de soi. En parallèle, ce séminaire encourage un espace de réflexion et de partage, dans lequel idées et stratégies sont échangées avec d’autres participant·e·s sur comment faire face et réussir dans des situations professionnelles souvent complexes et difficiles.
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\r\nJours 1 et 2 : 9h00 - 17h30
\r\nJour 3: 9h00 - 12h30
La performance en entreprise ne se mesure pas seulement aux résultats, mais à la manière dont les objectifs sont fixés, suivis et ajustés. Cette formation vous offre les outils essentiels pour gérer la performance de votre équipe avec précision et bienveillance.
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\r\nÀ travers des méthodes concrètes, des échanges en sous-groupes et des mises en situation, vous apprendrez à accompagner pertinemment votre collaborateur.trice durant tout le cycle de sa performance, de la fixation des objectifs à leur évaluation.
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\r\nA la fin de cette formation vous saurez comment rédiger des objectifs efficaces, réaliser des suivis motivants, donner des feedbacks constructifs et conduire des entretiens d’évaluation structurés. Rejoignez-nous pour maîtriser l'art de la gestion de la performance et accompagner vos collaborateurs.trices vers l’excellence !