Thesis Director: Prof. J. Schmale,
\r\nCivil and Environmental Engineering doctoral program
\r\nThesis Nr. 11505
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\r\nTo take part in the public defense, please contact directly the speaker
Postdoc.Mobility fellowships provide support for a research stay abroad (24 months), for researchers who have done a doctorate and who wish to pursue a scientific or an academic career in Switzerland. NEXT APPLICATION DEADLINE. 05.08.2025 17:00 Swiss time
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\r\nThe SNSF is organising an online event to present the Postdoc.Mobility fellowships on 12 May 2025, from 10:00 to 11:30 (Swiss time). The presentation of the funding scheme will be followed by a Q&A session. Interested persons can register now via this link.
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\r\nThe fellowship covers:\r\n
During a one-week Summer Workshop in Central London, students will explore drawing as a fundamental tool in architecture and engineering, engaging with the site as both a built environment and a historically transformed place. Developed in collaboration with Drawing Matter, London, the workshop integrates hands-on drawing with research into the Drawing Matter Collection, a unique archive of architectural drawings.
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\r\nProject Team 2025
\r\nDr. Patricia Guaita, architect, lecturer, IA ENAC EPFL
\r\nRaffael Baur, architect and external lecturer ENAC EPFL
\r\nNiall Hobhouse, collector and writer, Drawing Matter Director
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\r\nInvited expert
\r\nMatthew Wells, Lecturer in Architectural Studies at University of Manchester
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\r\n![\"\"](\"//memento.epfl.ch/public/upload/fckeditorimage/40/0d/ed493c2f.jpg\")
The project aims to further investigate the structural, architectural, environmental, and social dimensions of TRC and its applications, particularly in the context of a new Multi-Purpose Space for the Department of Architecture & Interior Design Kenyatta University Campus, Nairobi, Kenya in collaboration with Urko Sanchez Architects. The space is intended to support academic, social, and experimental activities while serving as a living laboratory for sustainable and alternative construction methods. The pavilion should function not only as a usable academic space but also as a pedagogical tool, demonstrating climate-responsive design, material innovation, and adaptability over time. \r\n
![\"\"](\"//memento.epfl.ch/public/upload/fckeditorimage/7a/dc/2b0d232e.jpg\")
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\r\nRegistration is required to attend the full event, take part in the social activities and present a poster at the poster session (if any). However, the EPFL community is welcome to attend specific lectures without registration if the topic is of interest to their research. Do not hesitate to contact the CECAM Event Manager if you have any question.
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\r\nDescription
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\r\nDNA is a dramatic example of a multiscale system, where Å-scale details impact the global properties of a meter-long fiber and where femtosecond processes can impact on the entire genome years later. This implies that any theoretical study on DNA should take into consideration the vast variety of space and time scales, making it necessary the adoption of multi-physics approaches, covering the entire range of theoretical methods from quantum chemistry to rough mesoscopic models. Within this scenario the importance of data to bias simulations and as a reference to calibrate low resolution methods (Dans et al. 2017; Neguembor et al. 2022; Schultz et al. 2025).
\r\nLarge efforts have been made to develop accurate low level DFT and semiempirical methods that can be data-providers for a new generation of force-field, as well as integrated in QM/MM packages for an efficient representation of DNA reactivity (Aranda et al. 2019). Atomistic force-field have gained accuracy, showing good ability to reproduce unusual forms of DNA and long segments of DNA in the context of chromatin (Collepardo-Guevara et al. 2015; Genna et al. 2025) and providing very useful data for the calibration of lower level coarse-grained or mesoscopic methods(De Pablo 2011; Farré-Gil et al. 2024) ,which have gained sequence specificity, scalability and computational efficiency, allowing to simulate kilo-to-megabase fragments of DNA. Very remarkable efforts have been made to move up these methods to represent chromatin, which requires the introduction of biases derived from experimental data (MNAseq, chromosome conformation capture, and even static or dynamic pictures obtained by ultra-resolution microscopy, and others (Buitrago et al. 2019; Neguembor et al. 2022; Li and Schlick 2024)). This has opened the possibility to recover dynamic “base-pair” resolution pictures of chromatin and study aspects from local and global chromatin rearrangements to inter-play between effector proteins and nucleosomes, the impact of lesions in chromatin structure, and even the role of phase separation in defining local chromatin arrangements (Joseph et al. 2021; Liu et al. 2025; Park et al. 2025).
\r\nAs the target systems move from the small atomistic detail to the entire chromatin fiber, the community is broken into different sub-communities. This generates a risk of disconnection, which would lead to a waste of effort reformulating solutions to already solved problems, or ignoring the characteristic that a method should have to maintain coherence with more accurate models, or to scale to represent systems of real biological interest. This will be the main objective of this meeting, which will join a variety of sub-communities with a common interest: the DNA.
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\r\nReferences
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\r\n[1] J. Aranda, M. Terrazas, H. Gómez, N. Villegas, M. Orozco, Nat. Catal., 2, 544-552 (2019)
\r\n[2] D. Buitrago, L. Codó, R. Illa, P. de Jorge, F. Battistini, O. Flores, G. Bayarri, R. Royo, M. Del Pino, S. Heath, A. Hospital, J. Gelpí, I. Heath, M. Orozco, Nucleic Acids Research, 47, 9511-9523 (2019)
\r\n[3] R. Collepardo-Guevara, G. Portella, M. Vendruscolo, D. Frenkel, T. Schlick, M. Orozco, J. Am. Chem. Soc., 137, 10205-10215 (2015)
\r\n[4] P. Dans, I. Ivani, A. Hospital, G. Portella, C. González, M. Orozco, Nucleic. Acids. Res., gkw1355 (2017)
\r\n[5] J. de Pablo, Annu. Rev. Phys. Chem., 62, 555-574 (2011)
\r\n[6] D. Farré-Gil, J. Arcon, C. Laughton, M. Orozco, Nucleic Acids Research, 52, 6791-6801 (2024)
\r\n[7] V. Genna, G. Portella, A. Sala, M. Terrazas, I. Serrano-Chacón, J. González, N. Villegas, L. Mateo, C. Castellazzi, M. Labrador, A. Aviño, A. Hospital, A. Gandioso, P. Aloy, I. Brun-Heath, C. Gonzalez, R. Eritja, M. Orozco, Nucleic Acids Research, 53, (2025)
\r\n[8] J. Joseph, A. Reinhardt, A. Aguirre, P. Chew, K. Russell, J. Espinosa, A. Garaizar, R. Collepardo-Guevara, Nat. Comput. Sci., 1, 732-743 (2021)
\r\n[9] Z. Li, T. Schlick, Nucleic Acids Research, 52, 583-599 (2023)
\r\n[10] S. Liu, C. Wang, B. Zhang, Biochemistry, 64, 1750-1761 (2025)
\r\n[11] M. Neguembor, J. Arcon, D. Buitrago, R. Lema, J. Walther, X. Garate, L. Martin, P. Romero, J. AlHaj Abed, M. Gut, J. Blanc, M. Lakadamyali, C. Wu, I. Brun Heath, M. Orozco, P. Dans, M. Cosma, Nat. Struct. Mol. Biol., 29, 1011-1023 (2022)
\r\n[12] S. Park, R. Merino-Urteaga, V. Karwacki-Neisius, G. Carrizo, A. Athreya, A. Marin-Gonzalez, N. Benning, J. Park, M. Mitchener, N. Bhanu, B. Garcia, B. Zhang, T. Muir, E. Pearce, T. Ha, Nature, (2025)
\r\n[13] E. Schultz, J. Kaplan, Y. Wu, S. Kyhl, R. Willett, J. de Pablo, WIREs. Comput. Mol. Sci., 15, (2025)
A summer school taking place this September will bring together EPFL and ETH Zurich PhD students to explore how uncertainty can become a productive resource in design and fabrication through a hands-on construction robotics challenge.
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\r\nThe program combines lectures in architecture, robotics, and work psychology with the full-scale construction of a timber structure from irregular timber stock, using an ABB industrial robot in a human-robot fabrication workflow.
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\r\nNo previous experience in construction robotics is required, only curiosity.
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\r\nMore details, including the program, dates, and registration information, are available on the website: https://cap-uncertainty.epfl.ch/
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\r\nFor questions, please contact: cap-uncertainty@epfl.ch
Thesis Director: Prof. A.-M. Kermarrec,
\r\nComputer and Communication Sciences doctoral program
\r\nThesis Nr. 11369
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\r\nTo take part in the public defense, please contact directly the speaker
Eine App programmieren? Ein Computerspiel erfinden? Eine Animation gestalten?
\r\nWenn dich eines dieser Dinge interessiert, bist du hier am richtigen Ort! Tausche und teile deine Ideen, lerne zu programmieren und entdecke Informatikberufe.
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\r\nDie Coding Club for Girls Workshops sind für Mädchen im Alter von 11 bis 15 Jahren und die Teilnahme ist kostenlos. Ab der Teilnahme an vier Workshops pro Jahr wird eine Teilnahmebestätigung ausgehändigt.
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\r\nOrt: Benedict Schule, Bern
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\r\nDatum und Zeit:
\r\n05. September 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Scratch-me
\r\n12. September 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Minitel
\r\n17. Oktober 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Snake-it
\r\n24. Oktober 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Webdesignerin
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\r\nDie Inhalte der Workshops sind untenstehend beschrieben.
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\r\nBedingungen\r\n