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\r\nOpen-source hardware can play a unique role for the semiconductor industry in the age of sustainable AI. It can enable design reuse, foster collaboration, and support workforce development. ESP (Embedded Scalable Platforms) is an open-source research platform for system-on-chip (SoC) design that combines a modular architecture with an agile design methodology. The ESP architecture simplifies the design and prototyping of heterogeneous chips with multiple RISC-V processor cores and dozens of loosely coupled accelerators, all interconnected by a scalable network-on-chip. The ESP methodology promotes system-level design while accommodating different specification languages and design flows.
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\r\nESP's capabilities have enabled a small team, primarily composed of graduate students, to realize two SoCs of increasing complexity, each within a few months. Conceived as a heterogeneous system integration platform and refined through years of teaching at Columbia University, ESP is well suited to advance collaborative engineering across the open-source hardware community.
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\r\nThis talk will be followed by a standing lunch in BC420 from 12:15 to 13:30.
The MARVEL Junior Seminar series is continuing in hybrid mode, in order to maintain in-person contacts and allow off-campus attendees to follow the seminars remotely! The MARVEL Junior Seminars aim to intensify interactions between the MARVEL Junior scientists belonging to different research groups. The seminar consists of two 25-minute presentations, followed by time for discussion.
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\r\nZacharie Waysenson
\r\nLaboratoire de Physique de l’École Normale Supérieure, Sorbonne Université
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\r\nMaria Andolfatto
\r\nLaboratory for Materials Simulations, PSI
It is becoming increasingly common to issue forecasts that are probabilistic, in the form of probability distributions over all possible outcomes. To generate good probabilistic forecasts, we must first be able to evaluate how good a forecast is. The evaluation of probabilistic forecasts focuses on two aspects of forecast performance: forecast accuracy and forecast calibration. Forecast accuracy refers to how 'close' the forecast is to the corresponding observation, which can be quantified using proper scoring rules. Forecast calibration considers whether probabilistic forecasts are trustworthy. While most scoring rules and calibration checks treat all possible outcomes equally, some outcomes are often of more interest than others when evaluating forecasts, and one could argue that these outcomes should therefore be emphasised during forecast evaluation. For example, extreme outcomes typically lead to the largest impacts on forecast users, making accurate and calibrated forecasts for these outcomes particularly valuable. In this talk, we discuss methods to focus on particular outcomes when evaluating probabilistic forecasts. We review weighted scoring rules, which allow practitioners to incorporate a weight function into conventional scoring rules when calculating forecast accuracy, and we demonstrate that the theory underlying weighted scoring rules can readily be extended to forecast calibration. Using this, we introduce methods to evaluate the calibration of probabilistic forecasts for extreme events.
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Thesis Directors: Dr. S. Mischler, Dr A. N. Igual Muñoz
\r\nMaterials Science and Engineering doctoral program
\r\nThesis Nr. 11619
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\r\nTo take part in the public defense, please contact directly the speaker
You can apply to participate and find all the relevant information (speakers, abstracts, program,...) on the event website: https://www.cecam.org/workshop-details/challenges-in-modelling-ion-channels-simulations-meet-experiments-1369.
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\r\nRegistration is required to attend the full event, take part in the social activities and present a poster at the poster session (if any). However, the EPFL community is welcome to attend specific lectures without registration if the topic is of interest to their research. Do not hesitate to contact the CECAM Event Manager if you have any question.
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\r\nDescription
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\r\nThe human genome includes more than 300 genes coding for ion channel proteins, representing approximately 2% of the total number of genes. This abundance of ion channels highlights their critical role in numerous biological processes and their involvement in diseases, underscoring their importance as potential drug targets. Ion channels exert their biological roles through three main functional characteristics: the highly efficient selective conduction of ions; the capacity to open and close in response to chemical/physical stimuli (gating); and the decrease in conductance upon sustained stimuli (inactivation). In the last 20 years, the number of experimental atomic structures of ion channels has increased from a few units to hundreds, now including representative structures for most of the ion channel families. Simulations based on these experimental structures have significantly contributed to the current understanding of conduction, selectivity, gating, and inactivation [1-2]. Strengthening the quantitative agreement between simulations and experiments is now essential for advancing in this field. This effort is currently hampered by common issues in biomolecular simulations, such as the limited timescales for observing biologically relevant events and the sub-optimal accuracy of the underlying physical models. Both of these shortcomings are expected to be mitigated by recent methodological developments. For instance, atomic simulations of ion channels with polarizable force fields have been recently reported [3]. Lack of polarization is a well-known limitation of classical force fields, especially when describing ion-protein and ion-water interactions in a crowded environment like the pore cavity. Consequently, the usage of polarizable force fields is considered a promising strategy for improving the agreement with experimental data about ion conduction and selectivity. An alternative strategy for enhancing the model accuracy in critical channel regions is to combine molecular mechanics with quantum approaches. Thanks to the ever-increasing computational resources, now combined with advancements in codes for hybrid QM/MM models, this approach is becoming feasible for ion channel research [4]. Increasing computational resources, coupled with improved algorithms for accelerating rare events and potentially harnessing machine learning, are also opening new possibilities in the study of state transitions. Gating and inactivation events of ion channels are finally becoming accessible to atomic simulations, offering important insights into the mechanistic functioning of this important protein superfamily [5]. The proposed workshop will foster further developments in the field by bringing together leading scientists in the experimental methodologies and computational techniques used in ion channel research in a stimulating and collaborative environment.
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\r\nReferences
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\r\n[1] E. Flood, C. Boiteux, B. Lev, I. Vorobyov, T. Allen, Chem. Rev., 119, 7737-7832 (2019)
\r\n[2] C. Guardiani, F. Cecconi, L. Chiodo, G. Cottone, P. Malgaretti, L. Maragliano, M. Barabash, G. Camisasca, M. Ceccarelli, B. Corry, R. Roth, A. Giacomello, B. Roux, Advances in Physics: X, 7, (2022)
\r\n[3] V. Ngo, H. Li, A. MacKerell, T. Allen, B. Roux, S. Noskov, J. Chem. Theory Comput., 17, 1726-1741 (2021)
\r\n[4] F. Schackert, J. Biedermann, S. Abdolvand, S. Minniberger, C. Song, A. Plested, P. Carloni, H. Sun, J. Chem. Inf. Model., 63, 1293-1300 (2023)
\r\n[5] S. Pérez-Conesa, L. Delemotte, Free energy landscapes of KcsA inactivation, 2023
Join us for the third edition of the Lemanic Life Sciences Hackathon!
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\r\nOrganized by EPFL School of Life Sciences, EPFL AI Center and the University of Bern, we aim to bring together clinicians, life scientists, and data scientists to test ideas, drive innovation, and tackle real-world challenges in healthcare and research.
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\r\nExplore the untapped potential of AI in life sciences and clinical research\r\n
Eine App programmieren? Ein Computerspiel erfinden? Eine Animation gestalten?
\r\nWenn dich eines dieser Dinge interessiert, bist du hier am richtigen Ort! Tausche und teile deine Ideen, lerne zu programmieren und entdecke Informatikberufe. Die Coding Club for Girls Workshops sind für Mädchen im Alter von 11 bis 15 Jahren und die Teilnahme ist kostenlos.
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\r\nAb der Teilnahme an vier Workshops pro Jahr in Biel wird eine Teilnahmebestätigung ausgehändigt.
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\r\nOrt: Haute École Pédagogique BEJUNE, 2503 Biel
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\r\nDatum und Zeit:
\r\n21. Februar 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Webdesignerin
\r\n21. März 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Pixel Art
\r\n25. April 2026 : 09:30 bis 12:00 oder 13:30 bis 16:00 Uhr // Cyber Security
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\r\nDie Inhalte der Workshops sind untenstehend beschrieben.
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\r\nBedingungen\r\n
Depuis 2011, le CDH-Culture invite un·e artiste à présenter une œuvre en relation avec le Rolex Learning Center. Cette année, Séverin Guelpa, artiste basé à Genève, travaillant entre le Valais (les glaciers), les Etats-Unis (les déserts) et le Chili (Salar d’Atacama), propose une série de grandes sculptures évoquant les tremblements - géologiques, politiques ou écologiques - qui secouent notre monde.
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\r\nL’artiste a récupéré des pierres dans une carrière suisse, il ajoute des éléments réfléchissants, il compose avec des déchets métalliques et du bois de charpente. Ces œuvres, en équilibre-déséquilibre, manifestent les forces et les tensions, ainsi que les chutes, les glissements et les catastrophes possibles. Ces œuvres font aussi référence, de près ou de loin, aux événements intervenus récemment dans les villages de Blatten (Valais) ou de Brienz (Grisons), désormais célèbres pour leurs impressionnants glissements de terrain.
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\r\nElles interprètent librement cette période mouvementée que nous traversons et qui nous oblige à réfléchir à nos propres limites. Comme un écho à la période de turbulences que nous traversons, elles réfléchissent une forme de précarité, d’imprévisibilité ou encore de fragilité. Les morceaux d’acier poli interagissent directement avec le Rolex Learning Center qu’ils mettent en scène dans le tourbillon du monde.
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\r\nTremblement aborde des questions constructives mais aussi humaines et collectives. A l’allure à la fois technique et fragile, ces sculptures consistent en des mises en tension de matières et de formes, comme maintenues en équilibre par l’énergie de leur mise en œuvre. Ces éléments seront réalisés en collaboration avec différentes entreprises locales, dont une scierie du Val de Bagne, une carrière de la vallée du Rhône, une entreprise de façades métalliques à Fribourg et une autre de vitres à Bulle. A chaque fois, il s’agira au possible de recourir à des chutes de production ou à du bois issu d’abattage après tempête. Bois et pierre renvoient aux matières premières, métal et câble aux gestes et à la manutention humaine.
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\r\nVernissage le jeudi 9 octobre 2025 à 18h
\r\nExposition à voir jusqu'au 26 avril 2026
\r\nEntrée libre
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\r\nCette exposition bénéficie de l'apport généreux des partenaires suivants que nous remercions:
\r\nMTA Carrière (St-Léonard)
\r\nROCPAN SA et RAY SA (Givisiez)
\r\nScierie de la Rippe SARL
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\r\nL’ARTISTE
\r\nExplorateur des espaces extrêmes, observateur des actions humaines dans la nature, Séverin Guelpa (1974) cherche à agir avec les écosystèmes en vue de mieux les habiter. Son travail s’ancre dans les territoires fragiles, exposés, menacés – ces zones du globe où les tensions entre nature, ressources, économie et survie humaine sont les plus palpables. Depuis plusieurs années, il arpente déserts, zones arides, espaces industriels ou géographies en transition, pour y extraire une forme de vérité physique et poétique.
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\r\nDepuis 2014, Séverin Guelpa a été invité à participer à de nombreuses expositions, biennales et événements importants à travers le monde. Il a notamment exposé au Palais de Tokyo à Paris, au Museu do Amanhã à Rio de Janeiro, et a participé à des biennales internationales telles que celles de Mongolie, d’Athènes ou encore de Larnaca à Chypre. Ces invitations témoignent de la reconnaissance d’un travail engagé, qui place la matière et le territoire au cœur d’une réflexion artistique contemporaine.
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\r\nIl a fondé la plateforme collective MATZA qui s’est déployée dans le désert du Mojave (2014–2017), sur le glacier d’Aletsch (2016–2018), sur les îles Kerkennah en Tunisie (2017) puis en Colombie (Medellín et Cúcuta) et au Kenya (Nairobi) entre 2022 et 2023.
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\r\nAprès une formation en sciences politiques, Séverin Guelpa a obtenu un master en arts visuels à la HEAD – Genève. Il a depuis été invité à présenter son travail, à donner conférences et workshops dans de nombreuses institutions, universités et écoles d’art, en Suisse comme à l’international.\r\n
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