Prof. Hess Bellwald's Lab: Kelly Maggs - Discrete Hodge Theory and Single Cell RNA Velocity
Event details
Date | 11.05.2022 |
Hour | 16:00 › 16:45 |
Speaker | Kelly Maggs, BMI |
Category | Conferences - Seminars |
Event Language | English |
Hybrid - By invitation only
In 2018, La Manno et al. introduced a method for approximating the velocity of RNA levels in single cells. The information in each velocity vector is comprised of a complex combination of different biological processes and noise, and in this talk, we propose a method for separating the signal into meaningful components.
We will discuss a number of models, inspired by Topological Data Analysis, for discretizing RNA velocity. From here, one can use the tools of discrete Hodge theory which provide a natural way to deconvolve different components of the RNA velocity field. This talk will be self-contained, starting with a short introduction to simplicial complexes (which provide a discrete model of RNA expression space) and discrete Hodge theory.
Links
Practical information
- Informed public
- Invitation required
- This event is internal
Organizer
- Brain Mind Institute