BMI SEMINAR // Brenda Bloodgood - The unexpected precision of an activity-dependent transcription factor
Event details
| Date | 19.05.2021 |
| Hour | 17:00 › 18:00 |
| Speaker |
Brenda Bloodgood, Division of Biological Sciences, Department of Neurobiology University of California, San Diego, USA |
| Location | Online |
| Category | Conferences - Seminars |
Exceptionally at 05:00 PM
In neurons, activity-dependent transcription factors are expressed in response to a variety of stimuli and regulate gene expression that is associated with morphological, synaptic and circuit plasticity. Because of this, they are routinely used to identify behaviorally relevant neurons in vivo. Yet, it is unclear if a transcription factor conveys information to the nucleus about specific types of activity or how this information is transformed into changes in connectivity. I will share recent work from my lab describing how, in the mouse hippocampus, the transcription factor NPAS4 independently communicates changes in spiking and synaptic activity to the nucleus. This information is then converted into precise changes in inhibitory circuit connectivity that reconfigures the computations performed by the neuron.
In neurons, activity-dependent transcription factors are expressed in response to a variety of stimuli and regulate gene expression that is associated with morphological, synaptic and circuit plasticity. Because of this, they are routinely used to identify behaviorally relevant neurons in vivo. Yet, it is unclear if a transcription factor conveys information to the nucleus about specific types of activity or how this information is transformed into changes in connectivity. I will share recent work from my lab describing how, in the mouse hippocampus, the transcription factor NPAS4 independently communicates changes in spiking and synaptic activity to the nucleus. This information is then converted into precise changes in inhibitory circuit connectivity that reconfigures the computations performed by the neuron.
Practical information
- Informed public
- Free
Organizer
- SV BMI Host : P. Ramdya