Chemical Biology Routes to Engineer Protein-Protein Interaction

In the evolutionary arms race between host immune receptors and pathogen or cancer antigens, proteins undergo dynamic changes, including post-translational modifications (PTMs) and co-evolutionary mutations. My research aims to unravel these complex molecular interactions through the integration of chemical and synthetic biology approaches. First, I will discuss my work on chemical biology methods for site-specific protein modification, which advance our understanding of PTM biology. Next, I will describe the recently invented 'library-on-library' approaches designed to co-evolve protein-protein interactions and how this synthetic dataset can be used to train machine learning models for predicting novel interactions.