EPFL BioE Talks SERIES "Mitotic Bookmarking by Transcription Factors"
Event details
| Date | 16.05.2022 |
| Hour | 16:00 › 17:00 |
| Speaker | Pablo Navarro Gil, Ph.D., Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris (F) |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
WEEKLY EPFL BIOE TALKS SERIES
Abstract:
The changes that occur during mitosis often have dramatic effects on gene regulatory processes, which need to be accurately reinstated in the daughter cells. Whether sequence-specific transcription factors (TFs) contribute to gene reactivation after mitosis, particularly in the context of an intense and global burst of transcription occurring shortly after division, is not fully understood. While some TFs have been proposed to act as mitotic bookmarking factors driving gene reactivation after mitosis, whether this function is really executed by any TF is still today debatable. These questions will be discussed using pluripotent cells and the TFs CTCF, Esrrb, Nr5a2 and cMyc as illustrative examples.
Bio:
Education/Degree:
2018 HDR; UVSQ University
2002-2006 PhD; Paris VI University - «Logique du Vivant»
2001-2002 DEA (Cancerology); Institut Gustave Roussy / Paris XI
1999-2001 Master; École Normale Supérieure Ulm / Paris VII
1999-2003 École Normale Supérieure de Cachan
Positions:
2019-present Head of the EPIC Unit, Institut Pasteur
2016-present Coordinator of the Revive bioinformatics team, Institut Pasteur
2013-2018 Junior Group Leader (ECS G5), Institut Pasteur
2009-2013 Research associate with Pr.I. Chambers, University of Edinburgh
2006-2009 Research associate with Pr. P. Avner, Institut Pasteur
2002-2006 PhD studies with Dr. C. Rougeulle, Institut Pasteur
.
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
IF you are not attending in-person in the room, please make sure to
Abstract:
The changes that occur during mitosis often have dramatic effects on gene regulatory processes, which need to be accurately reinstated in the daughter cells. Whether sequence-specific transcription factors (TFs) contribute to gene reactivation after mitosis, particularly in the context of an intense and global burst of transcription occurring shortly after division, is not fully understood. While some TFs have been proposed to act as mitotic bookmarking factors driving gene reactivation after mitosis, whether this function is really executed by any TF is still today debatable. These questions will be discussed using pluripotent cells and the TFs CTCF, Esrrb, Nr5a2 and cMyc as illustrative examples.
Bio:
Education/Degree:
2018 HDR; UVSQ University
2002-2006 PhD; Paris VI University - «Logique du Vivant»
2001-2002 DEA (Cancerology); Institut Gustave Roussy / Paris XI
1999-2001 Master; École Normale Supérieure Ulm / Paris VII
1999-2003 École Normale Supérieure de Cachan
Positions:
2019-present Head of the EPIC Unit, Institut Pasteur
2016-present Coordinator of the Revive bioinformatics team, Institut Pasteur
2013-2018 Junior Group Leader (ECS G5), Institut Pasteur
2009-2013 Research associate with Pr.I. Chambers, University of Edinburgh
2006-2009 Research associate with Pr. P. Avner, Institut Pasteur
2002-2006 PhD studies with Dr. C. Rougeulle, Institut Pasteur
.
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
IF you are not attending in-person in the room, please make sure to
- send D. Reinhard a note before noon on seminar day, informing that you plan to attend the talk online, and
- be signed in on Zoom with a recognizable user name (not a pseudonym making it difficult or impossible to be identified).
Practical information
- Informed public
- Registration required
Organizer
- Prof. David Suter, EPFL
Contact
- Institute of Bioengineering (IBI), Dietrich REINHARD