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SUMMARY:DLN: The disconnectome\, Prof. Michel Thiebaut de Schotten\, CNRS
DTSTART:20211117T121500
DTEND:20211117T131500
DTSTAMP:20260506T123934Z
UID:5f435346fabdbe56dad62a5be67b922b2ab768fb62e9a0491db0f2ad
CATEGORIES:Conferences - Seminars
DESCRIPTION:Michel Thiebaut de Schotten\nAbstract\n\nWe commonly call gra
 y matter the outer layer of the brain (or cerebral cortex) devoted to the 
 most integrated cerebral functions\, such as visuospatial\, language or me
 mory skills. The cerebral cortex is composed of the cell bodies of neurons
 \, giving it its eponymous colour. Just as good communication between indi
 viduals is essential for the functioning of a society\, good communication
  between cortical regions is essential for brain function. In the brain\, 
 communication is enabled by tract-like extensions of neurons# -- axons -- 
 which group together in bundles to connect the different brain regions tog
 ether\, some of which reaching a length over 20 cm. True communication cha
 nnels\, in connecting the functions of several brain regions\, these white
  matter bundles allow the creation of new\, more complex functions similar
 ly to a group of letters that makes a full word with a specific meaning.\n
 For a long time\, research in human neuroscience has focused on the study 
 of brain functions associated with cortical regions. Brain imaging techniq
 ues developed in the early 2000s\, such as functional MRI for example\, ha
 ve made it possible to map brain functions (language\, logic\, memory\, et
 c.) on the surface of the cortex. But we can clearly see the limits of thi
 s approach\, which does not allow us to understand the relationships betwe
 en different cortical regions involved in the same function. With the adve
 nt of new imaging techniques making it possible to model white matter trac
 ts (for the past ten years or so)\, neuroscience is entering a new era whe
 re the anatomical support of brain functions is no longer considered only 
 as a collection of regions on the surface of the brain\, but as a network 
 of interconnected nodes communicating with each other. Based on one of the
  largest collection of brain damaged by stroke (1333 patients) combined wi
 th the most comprehensive meta-analysis database in neuroimaging (Neurosyn
 th) and the best current white matter mapping derived from the "Human Conn
 ectome 7T ”\, we produced the first-ever functional white matter atlas\,
  which alone maps more than 500 different functions in the brain. This atl
 as constitutes a conceptual and epistemological advance in human neuroscie
 nce since cerebral functions are no longer defined a priori and sought onl
 y in the cerebral cortex\, but they now emerge from the in-depth analysis 
 of white matter networks conceived as functional territories defined by th
 eir connectivity. By placing itself at the interface of basic research and
  medical research\, this atlas promises to be an essential tool for explor
 ing new brain functions and their circuits as well as for identifying typi
 cal stroke lesions which interrupt the circuits of the brain.\n\n\nBio\n\n
 With over ten years’ experience in neuropsychology and brain connectivit
 y neuroimaging\, Michel Thiebaut de Schotten benefits from an established 
 scientific track record and have made solid contributions to the field of 
 neuroscience. His work\, published in Science (2005)\, revealed that spati
 al neglect is a consequence of the disruption of communication between the
  frontal and the parietal lobes\, and thus should be considered as a disco
 nnection syndrome. Moreover\, he mapped\, for the first time\, the organiz
 ation of white matter anatomy in the healthy living human brain (Nature Ne
 uroscience 2011 as well as in the Atlas of the Human Brain Connections pub
 lished with Marco Catani in 2012). He have also pursued work concerning br
 ain connectivity in stroke populations by identifying new brain-behavior a
 ssociation and was recently published in Cerebral Cortex (2014-2015-2016).
  He is co-founder of the NatBrainLab \, founder of the BCBlab and plays a 
 key role as treasurer in the facilitation and in the organization of the H
 uman Brain Mapping annual conference. In 2014\, he was awarded the prestig
 ious British Neuropsychological Society’s Early Career Award\, The Eliza
 beth Warrington Prize as well as the European Society for Neuropsychology 
 Cortex prize. At present\, he is associate professor in Paris\, head of th
 e Brain Connectivity and Behaviour group (www.bcblab.com). Overall\, Miche
 l enjoys writing and sharing discoveries and new hypotheses about the huma
 n brain.
LOCATION:https://epfl.zoom.us/j/62710915382
STATUS:CONFIRMED
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