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SUMMARY:In the belly of the microglia: towards a quantitative dynamic unde
 rstanding of neuronal degradation in vivo
DTSTART:20211202T111500
DTEND:20211202T121500
DTSTAMP:20260916T014014Z
UID:dde1d9d77000b187c17da6ec6b667f56a4f48e4e0fb5f7e6e973a135
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Francesca Peri   \nDuring brain development\, neuronal
  precursors are generated in great excess. Only those that make functiona
 l connections survive\, while the vast majority undergoes apoptosis and is
  eliminated by microglia. It is clear that effective processing of these n
 eurons is essential\, but the underlying cellular mechanisms are poorly un
 derstood. Using living fish embryos\, we showed that neuronal cargo proces
 sing depends on the shrinkage and packaging of microglial phagosomes into 
 a unique cellular compartment\, the gastrosome\, with distinct molecular a
 nd ultrastructural characteristics. Loss of the transporter Slc37a2 blocks
  phagosomal shrinkage\, resulting in the expansion of the gastrosome and t
 he dramatic bloating of the cell. This\, in turn\, affects the ability of 
 microglia to phagocytose and migrate toward brain injuries. Thus\, mechani
 sms must exist in microglia to regulate uptake and maintain these cells' s
 urface area and functional morphology. We have discovered that the movemen
 t of the centrosome provides one such mechanism. Translocation of this org
 anelle towards forming phagocytic cups favors their closure and subsequent
  neuronal removal.  Thus\, the centrosome appears to limit the rate of n
 euronal engulfment\, and its targeted movement is sufficient to polarize 
 microglia and promote neuronal uptake. These findings provide powerful w
 ays to affect microglia and modulate the impact that these cells have in t
 he context of many neurodegenerative disorders.\n\nZoom password : 068519
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153 https://epfl.zoom.u
 s/j/66877625779?pwd=aGovTkhYMS9OLzlhL1lhNHlaWkR2Zz09
STATUS:CONFIRMED
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