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SUMMARY:EPFL BioE Talks SERIES  "Regulation of Gene Expression During the 
 Awakening of the Zygotic Genome"
DTSTART:20211206T160000
DTEND:20211206T170000
DTSTAMP:20260930T210902Z
UID:d42acff2b00f8b8f5f84f68f6af60e4ec800754a1439d05ddff7a5a7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Mounia Lagha\, Institute of Molecular Genetics\, Univers
 ity of Montpellier\, CNRS\, Montpellier (FR)\nWEEKLY EPFL BIOE TALKS SERIE
 S\n\nAbstract:\nA fundamental question in biology is how cellular processe
 s are so reproducible despite the inherent variations in the chemical reac
 tions governing them. During development of a multicellular organism\, pre
 cise control of gene expression allows the reproducible establishment of p
 atterns. Our goal is to elucidate the mechanisms responsible for precision
  in gene expression and to link them to accuracy in cell fate decisions. M
 y team tackles this question using the early development of Drosophila as 
 a model system\, during the maternal to zygotic transition. During this cr
 itical developmental window\, patterns of gene expression are rapidly esta
 blished with remarkable reproducibility and accuracy. We use quantitative 
 imaging\, genetic manipulations\, biophysics and mathematical modeling to 
 integrate the dynamic aspects of transcription and translation. In this ta
 lk\, I will summarize our recent results regarding the control of transcri
 ptional memory and transcriptional bursting by cis-regulatory elements and
  pioneer factors [1\, 2]. I will also present our recent deployment of the
  Suntag method to monitor translation in living Drosophila embryos\, that 
 lead to the discovery of intragenic translational heterogeneities [3].\n\n
 References:\n[1] Bellec M\, Dufourt J\, Hunt G\,  Lenden-Hasse H\, Trull
 o A\, Zine El Aabidine A\,  Lamarque M\, Gaskill M\,  Faure-Gautron H\,
  Mannervik M\, Harrison M\, -Christophe Andrau JC\,  Favard C\,  Radul
 escu O and Lagha# M (2021) The control of transcriptional memory by stable
  mitotic bookmarking. bioRxiv 2021.08.30.458146\; doi: 10.1101/2021.08.3
 0.458146 (submitted)\n\n[2] Pimmett V*\, Dejean M*\, Fernandez C\, Trullo 
 A\, Bertrand A\, Radulescu O and Lagha M# (2021) Quantitative imaging of t
 ranscription in living Drosophila embryos reveals the impact of core promo
 ter motifs on promoter state dynamics. Nature Communications\, DOI: 10.103
 8/s41467-021-24461-6.\n\n[3] Dufourt J#*\, Bellec M*\, Trullo A\,  Dejean
  M\, De Rossi S\, Favard C and Lagha M#  \nImaging translation dynamics i
 n live embryos reveals spatial heterogeneities\, Science (2021)\nApr 29\;e
 abc3483. DOI: 10.1126/science.abc3483\n\nBio:\nI am researcher in Developm
 ental Biology and my main interest is how gene expression is precisely est
 ablished during embryogenesis.\nMy initial training was on mouse myogenesi
 s (PhD obtained in 2008 at the Pasteur Institute in Paris under the superv
 ision of Pr M.Buckingham and F.Relaix). For my post-doc\, in order to obta
 in more mechanistic insights\, I changed model organism and studied transc
 riptional regulation during Drosophila development at UC Berkeley in the l
 ab of Pr M.Levine (2010-2014). My postdoctoral work revealed the importanc
 e of paused polymerase for the coordination of cell fate decisions during 
 gastrulation.\nSince 2015\, I am directing a group at IGMM in Montpellier 
 (www.laghalab.com) where we study mechanisms of transcriptional regulation
  in living Drosophila embryos. Our current research focuses on the role of
  promoters and enhancers on the dynamic aspects of transcription (transcri
 ptional synchrony\, bursting and memory). Recently we started also investi
 gating translational control during early development. We use a variety of
  approaches ranging from classical genetics\, molecular biology to quantit
 ative live imaging and biophysical techniques. We constantly collaborate w
 ith physicists and mathematicians to develop theoretical frameworks for a 
 better understanding of our quantitative biological data.\n\n\nIMPORTANT N
 OTICE:\nAs a consequence of the ongoing Covid-19 pandemic\, in-person atte
 ndance of this seminar is subjected to some constraints:\n\n	Maximum numbe
 r of participants is limited to 80 (2/3 of room SV1717's nominal capacity)
 : first come\, first served!\n	Valid COVID certificate and ID\, required t
 o enter the meeting room\, will be checked at the entrance\n	Face masks ar
 e mandatory for everyone in the seminar room (excepted the speaker while p
 resenting).\n\nThank you warmly for your understanding!\n\nAlternatively\,
  the seminar can also be followed via Zoom web-streaming:\nZoom link (with
  one-time registration for the whole series) for attending remotely: https
 ://go.epfl.ch/EPFLBioETalks\n\n\nInstructions for 1st-year Ph.D. students 
 who are under EDBB’s mandatory seminar attendance rule:\nIF you are not 
 attending in-person in the room\, please make sure to\n\n\n	send D. Reinha
 rd a note before noon on seminar day\, informing that you plan to attend t
 he talk online\, and\n	be signed in on Zoom with a recognizable user name 
 (not a pseudonym making it difficult or impossible to be identified).\n\nS
 tudents attending the seminar in-person should collect a confirmation sign
 ature after the talk - please print your own signature sheet beforehand (7
 1 kB pdf available for download here).
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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