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SUMMARY:EPFL Neuro Seminar // Peter R. Hiesinger - How does a neuron decid
 e when and where to make a synapse?
DTSTART:20220216T160000
DTEND:20220216T170000
DTSTAMP:20261002T033652Z
UID:e71f2a0bb35eb13bc2855e5c9dfaeb4b728dbece3f4ff40f82c3947f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Peter R. Hiesinger\, Institute for Biology\, Free University B
 erlin\, Germany\nPrecise synaptic connectivity is a prerequisite for the f
 unction of neural circuits\, yet individual neurons\, taken out of their d
 evelopmental context\, readily form unspecific synapses.  How does geneti
 cally encoded brain wiring deal with this apparent contradiction?  Brain 
 wiring is a developmental growth process that is not only characterized by
  precision\, but also flexibility and robustness.  As in any other growth
  process\, cellular interactions are restricted in space and time.  Corre
 spondingly\, molecular and cellular interactions are restricted to those t
 hat 'get to see' each other during development.  This seminar will explor
 e the question how neurons decide when and where to make synapses using th
 e Drosophila visual system as a model.  New findings reveal that pattern 
 formation during growth and the kinetics of live neuronal interactions res
 trict synapse formation and partner choice for neurons that are not otherw
 ise prevented from making incorrect synapses in this system.  For example
 \, cell biological mechanisms like autophagy as well as developmental temp
 erature restrict inappropriate partner choice through a process of kinetic
  exclusion that critically contributes to wiring specificity.  The semina
 r will explore these and other neuronal strategies when and where to make 
 synapses during developmental growth that contribute to precise\, flexible
  and robust outcomes in brain wiring.\n 
LOCATION:https://epfl.zoom.us/j/62550191552?pwd=OFRDVzBHb0cyVG1wYkxUSFFEMU
 NPdz09
STATUS:CONFIRMED
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