BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Prof. Schneggenburger's Lab: Shriya Palchaudhuri - An insular cort
 ex - lateral amygdala network in fear learning
DTSTART:20220209T160000
DTEND:20220209T164500
DTSTAMP:20260427T210729Z
UID:9a403049d01d408f7958975c5cbcee87eacf1435096c8cfd806b4ca1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Shriya Palchaudhuri\, BMI\nOnline by invitation only\n\nFear l
 earning is a behavioral paradigm which might allow to relate plasticity at
  specific synapses and - circuits\, to a learned behavioural response. The
  lateral amygdala (LA) has long been known to receive thalamic- and audito
 ry cortex inputs\, which undergo long-term plasticity during fear learning
 . Interestingly\, anatomical studies show that the posterior insular corte
 x (pInsCx) is also upstream to the LA\; furthermore\, the pInsCx has been 
 shown to process auditory\, somatosensory - nociceptive\, and interoceptiv
 e information. Here\, using in-vivo recordings\, in-vivo optogenetic techn
 iques\, and ex-vivo optogenetically -assisted circuit mapping\, we find th
 at the pInsCx plays a role in associative plasticity upstream of the LA. F
 urthermore\, the pInsCx to LA excitatory synapse transmits part of the foo
 tshock information to the LA\, and undergoes an increase in AMPA/NMDA rati
 o after fear learning. Our study suggests that aversively-motived associat
 ive plasticity can take place upstream of the amygdala\, a finding that pa
 rallels recent studies in thalamic areas.
LOCATION:
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR