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SUMMARY:Prof. Hess Bellwald's Lab: Kelly Maggs - Discrete Hodge Theory and
  Single Cell RNA Velocity
DTSTART:20220511T160000
DTEND:20220511T164500
DTSTAMP:20260506T165905Z
UID:8a8968f7ad3ca3a05f47e54c9fcbd0d0ad7ddb178ca5b2f2d3b9f260
CATEGORIES:Conferences - Seminars
DESCRIPTION:Kelly Maggs\, BMI\nHybrid - By  invitation only\n\nIn 2018\, 
 La Manno et al. introduced a method for approximating the velocity of RNA 
 levels in single cells. The information in each velocity vector is compris
 ed of a complex combination of different biological processes and noise\, 
 and in this talk\, we propose a method for separating the signal into mean
 ingful components. \n\nWe will discuss a number of models\, inspired by T
 opological Data Analysis\, for discretizing RNA velocity. From here\, one 
 can use the tools of discrete Hodge theory which provide a natural way to 
 deconvolve different components of the RNA velocity field. This talk will 
 be self-contained\, starting with a short introduction to simplicial compl
 exes (which provide a discrete model of RNA expression space) and discrete
  Hodge theory. \n 
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STATUS:CONFIRMED
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