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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:Optimal checkpoint strategies
DTSTART:20211124T123000
DTEND:20211124T150000
DTSTAMP:20260407T160122Z
UID:9066c6aa32b232f9c588a5c78cb574f80ac2c1a1cce4f92ef4c8d740
CATEGORIES:Conferences - Seminars
DESCRIPTION:Sahand Rahi\nSurveillance systems are critical for biological 
 systems. Cellular self-replication is monitored by checkpoints\, which arr
 est cells when errors are detected. However\, checkpoints are hardly explo
 red quantitatively. We were interested in checkpoint override\, the phenom
 enon that checkpoints 'give up' or 'override' when cells are faced with pe
 rsistent errors. We sought to find patterns to checkpoints override\, that
  is\, whether there are quantitative laws that describe how long checkpoin
 ts arrest before override. We investigated a theory that balances risk and
  speed for cells\, which required two parameters to be measured\, how fast
  errors are repaired and what the survival probability is if checkpoints o
 verride. We measured these parameters for the first time precisely. Based 
 on these data\, the theory predicted the optimal checkpoint override times
 . Measuring these times experimentally in cells with multiple DNA breaks\,
  we found a remarkably close match between theory and experiments. The uni
 versal nature of the balance between risk and self-replication opportunity
  is in principle relevant to many other systems\, suggesting potential fur
 ther applications of the theory.\n\nA snack will be offered on site.\n\nDu
 e to covid guidelines you will be asked for the COVID pass + ID card at th
 e entrance of the seminar room.\n\n!! Number of participants will be limit
 ed !!\nThanks for registering here : Doodle | Theory Lunch seminar\n 
LOCATION:GA 3 21 https://plan.epfl.ch/?room==GA%203%2021 https://epfl.zoom
 .us/j/66976192958
STATUS:CANCELLED
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