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SUMMARY:Prof. Petersen's Lab: Anastasiia Oryshchuk "Experience-dependent r
 epresentation of sensory-\, motor- and decision-related activity in primar
 y sensory\, motor\, and medial prefrontal cortical areas"
DTSTART:20220504T160000
DTEND:20220504T164500
DTSTAMP:20260919T120306Z
UID:6e187a699dfeb1ac72c7240fde3fb1ffe94df4700f94ebe1e377f00b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Anastasiia Oryshchuk\, BMI\nNew date & hybrid - By invitation 
 only\n\nGoal-directed behavior requires processing of incoming sensory inf
 ormation\, making appropriate decisions\, and generating relevant motor ou
 tputs. Yet\, how these diverse aspects of sensorimotor transformation aris
 e within the intricate neuronal networks of the mammalian brain remains to
  be determined. Here\, we investigated sensory\, decision\, and motor sign
 als in the whisker primary somatosensory cortex (wS1)\, the medial prefron
 tal cortex (mPFC)\, and the tongue-jaw primary motor cortex (tjM1) in mice
  trained to lick for reward in response to a brief single-whisker stimulus
  of varying amplitude. Optogenetic inactivation demonstrated the causal in
 volvement of all three areas during task execution. We then performed high
 -density extracellular recordings of neuronal firing in wS1\, mPFC\, and t
 jM1 of mice trained in the whisker-detection task (Trained mice). To under
 stand task-specific neuronal representations\, we recorded in another grou
 p of mice that were exposed to the same whisker stimuli\, but without bein
 g associated to reward (Exposed mice). Sensory-evoked activity in the abse
 nce of licking (i.e. Miss trials) was almost exclusively found in wS1 and 
 correlated with stimulus amplitude in both Trained and Exposed mice. All t
 hree cortical regions were strongly modulated by licking in both Trained a
 nd Exposed mice\, but only tjM1 neuronal activity was unchanged comparing 
 spontaneous (False alarms) and whisker-evoked (Hit trials) licking. Finall
 y\, decision-encoding neurons - with selective activity for Hit trials\, b
 ut not Miss or False alarm trials - were found mostly in mPFC and wS1. Our
  results point to distinct yet inter-related roles of cortical regions for
  goal-directed sensorimotor transformation.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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