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SUMMARY:ChemBio e-seminar by Prof. Danica Fujimori
DTSTART;VALUE=DATE:20220315
DTSTAMP:20260510T062910Z
UID:09103e41859731f062d4276a7969e46cc8da46a152796e5ea07fbdff
CATEGORIES:Conferences - Seminars
DESCRIPTION:https://pharmacy.ucsf.edu/danica-galonic-fujimori  \nTitle: C
 hemical Biology of Methylation-Dependent Chromatin Recognition\n\nAbstract
 : Lysine methylation is a functionally diverse chromatin modification that
  regulates a number of cellular processes including heterochromatin format
 ion\, transcriptional regulation and DNA repair. The spatial and temporal 
 control of histone methylation is achieved by opposing activities of histo
 ne modifying enzymes - methyltransferases\, enzymes that deposit methylati
 on marks\, and demethylases\, enzymes that remove them. Methylation states
  of chromatin are recognized by methylation reader domains. Misregulation 
 of methylation is associated with disease\, including cancer and neurodege
 neration\, and inhibitors of methylation regulators offer promising new av
 enue in oncology. In this talk\, I will discuss our recent efforts on unde
 rstanding functions of plant homeodomain family of readers of chromatin me
 thylation\, and development of modulators for this family of epigenetic pr
 oteins.\n\nSpeaker's Biography: Danica Galonić Fujimori is a professor of
  Cellular and Molecular Pharmacology and Pharmaceutical Chemistry\, associ
 ate director of Quantitative Biosciences Institute and associate director 
 of Chemical Biology graduate program at University of California in San Fr
 ancisco. Organic chemist by graduate training (2005 PhD from UIUC\, with W
 ilfred van der Donk and the late David Gin) and mechanistic enzymologist b
 y postdoctoral training (with Chris Walsh at Harvard Medical School\, 2008
 )\, her lab combines organic chemistry and biochemical reconstitution to i
 nvestigate posttranslational and posttranscriptional regulation of macromo
 lecules. Her work has been recognized by a number of awards including V fo
 undation Scholar\, NSF Career award\, Searle Scholar\, and WM Keck Medical
  Research Award.\n\nLab website: http://fujimorilab.ucsf.edu 
LOCATION:https://epfl.zoom.us/j/69385437520
STATUS:CONFIRMED
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