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SUMMARY:ChemBio e-seminar by Prof. Brian Liau
DTSTART:20220503T161500
DTEND:20220503T171500
DTSTAMP:20260408T080233Z
UID:506efb757fbb627bd4fa7a79d2a333021e1ec7bd0e22f2b9e1160c36
CATEGORIES:Conferences - Seminars
DESCRIPTION:https://chemistry.harvard.edu/people/brian-liau\nTitle: Unrave
 ling Chromatin with Chemical Genomics\n\nAbstract: Biological macromolecul
 es participate in intricate\, complex interactions. These interactions spa
 n different shapes\, sizes\, and length scales\, from shape-complementary 
 surfaces that comprise stable protein complexes to weak chemical forces th
 at give rise to biomolecular condensates. This breadth and diversity is ex
 emplified by chromatin complexes\, the orchestrated interactions of which 
 control gene expression and cell fate decisions. Dysregulation of these co
 mplexes and their interactions underlie human disease\, and new therapeuti
 c approaches to modulate them by blocking or even creating interactions ar
 e transforming paradigms for drug discovery. Unraveling these complexes an
 d their interactions requires integrating deep understanding of their chem
 ical details with that of their dynamics and function in living cells. To 
 bridge these gaps\, my research program combines chemical biology with gen
 omic technologies to illuminate chromatin complexes and their functions in
  native\, cellular ecosystems. In this lecture\, I will describe how the a
 pplication of these tools in combination with deep mechanistic investigati
 on has led to unexpected biological discoveries that reshape our views on 
 targeting chromatin modifying enzymes for therapeutics.\n\nSpeaker's Biogr
 aphy: Brian Liau is an associate professor in the Department of Chemistry 
 and Chemical Biology at Harvard University. He obtained his bachelor’s d
 egree in Chemistry and Physics from Harvard College\, before receiving a P
 hD in Chemistry from Harvard University under the guidance of Dr. Matthew 
 Shair. During his PhD studies\, Brian completed the chemical synthesis of 
 complex bioactive natural products and investigated their biological mecha
 nism of action. As a postdoctoral fellow with Dr. Bradley Bernstein at Mas
 sachusetts General Hospital\, he studied epigenetic mechanisms of adaptati
 on and drug resistance in brain cancer. In 2016\, Brian started his indepe
 ndent research group\, which integrates genomics with chemical biology to 
 unravel chromatin complexes and genome regulation. In particular\, the Lia
 u lab has pioneered chemical genomic approaches to systematically identify
  drug resistance-conferring mutations for protein drug targets\, which the
 y leverage in deep mechanistic studies to discover new target biology.\n\n
 Lab website: www.liaulab.com
LOCATION:https://epfl.zoom.us/j/65487507571
STATUS:CONFIRMED
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