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SUMMARY:ChemBio e-seminar by Prof. Mohammad R. Seyedsayamdost
DTSTART:20220517T161500
DTEND:20220517T171500
DTSTAMP:20260510T081829Z
UID:d369ad96cb8360d31be150152e3bdd5be6066e9c87daab0791206fe1
CATEGORIES:Conferences - Seminars
DESCRIPTION:https://chemistry.princeton.edu/faculty/mohammad-r-seyedsayamd
 ost\nTitle: Discovering New Chemistry in the Microbial World\n\nAbstract: 
 Microbial natural products serve as a dominant source of pharmaceutical ag
 ents and comprise some of our most celebrated cures. Recent studies\, howe
 ver\, have been plagued by the frequent rediscovery of old molecules. One 
 underlying reason is that most natural product biosynthetic genes in a giv
 en bacterium are not significantly expressed under standard laboratory gro
 wth conditions. These so-called ‘silent’ or ‘cryptic’ gene cluster
 s represent a large reservoir of bioactive metabolites and methods that un
 lock them would have a profound impact on natural product research and the
 reby on drug discovery. In this talk\, I will present new strategies that 
 my group has developed for activating silent biosynthetic gene clusters an
 d uncovering novel 'hidden' natural products with activities that\, in som
 e cases\, surpass those of clinically used drugs. Aside from new natural p
 roducts\, application of these approaches to diverse bacteria has also unv
 eiled small molecule elicitors and the underlying mechanisms through which
  they turn on microbial natural product biosynthesis.\n\nSpeaker's Bio: Mo
 hammad R. Seyedsayamdost is Professor of Chemistry and Molecular Biology a
 t Princeton University. He obtained a combined B.S./M.S. degree in Biochem
 istry from Brandeis University\, completing his thesis research with Prof.
  Liz Hedstrom. He then conducted graduate research under the guidance of P
 rof. JoAnne Stubbe and received a Ph.D. in chemistry from MIT. After postd
 octoral training with Prof. Jon Clardy and Prof. Roberto Kolter at Harvard
  Medical School\, he started his independent career at Princeton. Prof. Se
 yedsayamdost's research has been recognized by a number of awards\, most r
 ecently with the prestigious MacArthur Fellowship. \n\nLab website: https
 ://mo.princeton.edu/\n 
LOCATION:https://epfl.zoom.us/j/61545265587
STATUS:CONFIRMED
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