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SUMMARY:Transforming Growth beta (TGF-b) signaling in T cells  protects fr
 om intestinal cancer
DTSTART:20220427T131500
DTEND:20220427T141500
DTSTAMP:20260504T082312Z
UID:2c487ab317b5a4ed78b6c501b2f0cfd989f46408b603adf883b2a97b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Julien MARIE\, CRCL : Cancer Research Center of Lyon \n
 Transforming growth factor β (TGF-β) is secreted by cancer cells in many
  solid tumors and can mediate potent immune-regulatory effects. TGF-β s
 ignaling within T lymphocytes impairs their ability to kill cancer cells\,
  but interfering with this activity can provoke fatal T cell-mediated auto
 immunity. Large amounts of cancer cell-derived TGFβ tend to be stored in 
 the extracellular matrix in an inactive latent form. Recent work from the 
 Marie lab revealed that this latent pool can be activated by tumor-infiltr
 ating regulatory T cells through their expression of integrin αvβ8. Th
 is unique cooperation between cancer cells and Tregs favors tumor immune 
 escape by creating an immunosuppressive micro-environment for effector T c
 ells. On the other hand\, unpublished work presented in this seminar revea
 ls an unexpected mechanism by which TGF-β signaling in differentiated Th1
 7 cells instead protects intestinal epithelial cells against transformatio
 n. Analysis of loss and gain of TGF-β receptor signaling specifically in 
 already differentiated Th17 cells\, combined with in vivo fate mapping and
  with single cell (sc) RNA-seq\, scATAC-seq and scMethylome approaches sh
 ows that epigenetic stabilization of the Th17 cell program by TGF-β preve
 nts them from inducing cancer. Taken together\, these studies shed import
 ant new light on how TGF-β can promote or inhibit tumor formation dependi
 ng on the context.\n\nRelated publications from the Marie lab:  Marie et 
 al Immunity 2006\, Havenar-Daughton Blood 2012\,  Soudja et al Immunity 2
 012\, Mc Carron et al.\, Journal of Clinical Investigation 2014\, Ruiz et 
 al.\, Nature communications 2014\, Worthington et al.\, Immunity 2015\,  
 Mc Carron et al.\, Nature communications 2019\, Ferreira et al.\, Nature I
 mmunology 2020\, Lainé et al.\, Nature communications 2021\, Igalouzene e
 t al.\, J.\nournal of Clinical Investigation 2022
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64562256398
STATUS:CONFIRMED
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