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SUMMARY:Mitochondrial communication: from metabolism to therapies
DTSTART:20220310T091500
DTEND:20220310T100000
DTSTAMP:20260920T093112Z
UID:2a8fd585c13953a11fb72536f2d7960c7a3c419a42a1dbc146f18201
CATEGORIES:Conferences - Seminars
DESCRIPTION:Carles Canto\, Junior Group Leader\, Nestle Institute of Healt
 h Sciences (NIHS)\, Lausanne\, Switzerland\nAbstract: \n\nMitochondrial d
 ysfunction is a hallmark for multiple metabolic and age-related diseases. 
 Beyond their respiratory capacity\, mitochondria constitute cellular 
 centers for the integration of metabolic information\, which they communic
 ate with other organelles through direct physical interactions or by expor
 ting metabolites. In this talk we’ll describe how mitochondria communic
 ate among themselves and with other organelles through mechanisms of mito
 chondrial fusion and fission. In particular\, we will focus on the ability
  of mitochondria to communicate to lipid droplets through the mitofusin-2 
 (Mfn2) protein. Second\, we will recapitulate the evidence suggesting that
  situations of mitochondrial dysfunction can be therapeutically approached
  by increasing cellular NAD+ levels through the dietary supplementation wi
 th NAD+ precursors. Multiple NAD+ precursors exist\, but we’ll argue tha
 t not all them will be effective to treat metabolic disorders and highligh
 t the main challenges for clinical translation.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/63499628779
STATUS:CONFIRMED
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