BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioE Talks SERIES  "Mechanical Engineering of Protein Therape
 utics"
DTSTART:20220314T160000
DTEND:20220314T170000
DTSTAMP:20260916T064704Z
UID:d314049682aaf6e507af36fbf799e7ac376c1fdd4e7b31b8c08bf82c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Michael A. Nash\, Department of Biosystems Science & Eng
 ineering\, ETH Zurich\, and Department of Chemistry\, University of Base
 l (CH)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbstract:\nProtein mechanical pro
 perties are known to play an important role in vivo\, but are currently ig
 nored in the development of engineered biotherapeutics. This talk will hig
 hlight recent work in the Nash Lab towards enhancing the activity of molec
 ular therapeutics through mechanical effects. We present a new paradigm 
 for enhancing the mechanical strength of therapeutic binding proteins base
 d on optimal selection of anchor points within a molecule. We report bio
 -orthogonal protein engineering and single-molecule AFM force spectroscopy
  protocols for applying tension to therapeutic affibody-PDL1 and anticali
 n-CTLA4 complexes through arbitrary residues positions within the scaffol
 d sequence. We show how a classical slip bond interaction can be converte
 d into a force-activated catch bond through selection of anchor points\, w
 ithout requiring mutagenesis. In the future\, we will develop these conce
 pts towards enhanced nanoparticle delivery to cells under shear flow.\n\n
 Bio:\nProf. Michael Nash earned a Bachelor of Science in Cybernetics with 
 a concentration in Biomedical Systems\, graduating with highest honors fr
 om UCLA in 2006. He held research internships at the Caltech NASA Jet Pro
 pulsion Lab\, the Pacific Northwest National Lab\, and the Biomedical Eng
 ineering Department at the University of New South Wales in Sydney\, Aust
 ralia. He earned a dual PhD degree in Bioengineering and Nanotechnology fr
 om the University of Washington\, Seattle in 2010. Following Postdoctoral
  work in applied physics at LMU Munich from 2011-​2012\, he was promote
 d to Group Leader in May 2013. Michael started as tenure-​track Assista
 nt Professor with joint appointments at the University of Basel\, Departm
 ent of Chemistry\, and at ETH Zurich\, Department of Biosystems Science & 
 Engineering in September 2016\, and was promoted to Associate Professor i
 n August 2021. \n\n\n\nZoom link (with one-time registration for the whol
 e series) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nIn
 structions for 1st-year Ph.D. students who are under EDBB’s mandatory se
 minar attendance rule:\nIF you are not attending in-person in the room\, p
 lease make sure to\n\n	send D. Reinhard a note before noon on seminar day\
 , informing that you plan to attend the talk online\, and\n	be signed in o
 n Zoom with a recognizable user name (not a pseudonym making it difficult 
 or impossible to be identified).\n\nStudents attending the seminar in-pers
 on should collect a confirmation signature after the talk - please print y
 our own signature sheet beforehand (71 kB pdf available for download here)
 .
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR