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SUMMARY:BMI Special Seminar // Gioele La Manno - "Revealing the molecular 
 and cellular architecture of the nervous system”
DTSTART:20220406T130000
DTEND:20220406T140000
DTSTAMP:20260429T081812Z
UID:9e07d342ae48392f7da106b99f7660a498dff3adab1d838f4fe96683
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gioele La Manno\, EPFL\nFrom the early histological observatio
 ns by Cajal\, the field of neurobiology has accumulated a monumental amoun
 t of knowledge about the molecular and cellular complexity of the brain. N
 onetheless\, only recently\, a system-level classification of its molecula
 r and cellular complexity has become technologically feasible. \nIn this 
 talk\, I will discuss the contributions of my lab to the description of th
 is complexity and how it is generated during development. I will\, first\,
  present a single-cell transcriptome atlas of mouse brain development span
 ning from gastrulation to birth and describe how spatially-resolved transc
 riptomic data can complement and be used to map cell states more precisely
 . Continuing on spatial profiling\, I will describe an approach that we de
 veloped to resolve different types of next-generation sequencing data spat
 ially. I will showcase the technique with the profiling of the brain of th
 e Australian bearded dragon. Finally\, I will summarize the most recent ef
 forts of the lab to study the dynamics of interconversion of intermediate 
 cell states and their implication for future treatment of neurodegenerativ
 e conditions.\n 
LOCATION:https://epfl.zoom.us/j/63839176159?pwd=NlQvNVFncEZwVWhJUWN5OFpaZT
 c3QT09
STATUS:CONFIRMED
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