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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:ChemBio e-seminar by Prof. Rebecca Butcher
DTSTART;VALUE=DATE:20220426
DTSTAMP:20260609T210832Z
UID:5ce7a335adb91fb5e67a338b78cf4562213e817d8b544a27cb40f1ef
CATEGORIES:Conferences - Seminars
DESCRIPTION:https://www.chem.ufl.edu/about-all/directory/people/name/rebec
 ca-butcher\nTitle: Decoding the chemical signals of the worm\n\nAbstract: 
 The nematode C. elegans uses small molecules to communicate with other wor
 ms and to control fundamental processes\, such as development\, metabolism
 \, fertility\, and lifespan.  This talk will describe our work on two imp
 ortant classes of natural products from C. elegans\, the ascarosides and t
 he nemamides.  C. elegans secretes ascarosides\, derivatives of the 3\,6-
 dideoxysugar ascarylose\, as pheromones to coordinate its development and 
 behavior. We are using a multidisciplinary approach\, including RNAi-based
  screens\, metabolomics\, in vitro enzyme assays\, organic synthesis of bi
 osynthetic intermediates\, and X-ray crystallography\, to study the ascaro
 side biosynthetic pathway.  Our work has shown how the worm uses peroxiso
 mal b-oxidation to control the chemical message that it produces and how e
 nvironmental conditions and other factors influence this message.  In a s
 econd area of research\, we have used comparative metabolomics and NMR spe
 ctroscopy to discover the first hybrid polyketide-nonribosomal peptides fr
 om an animal\, the nemamides from C. elegans.  We are using CRISPR-Cas9 a
 nd comparative metabolomics to map the role of specific enzymatic domains 
 in nemamide biosynthesis.  Our work is providing insights into the biosyn
 thesis of natural products in the context of a complex animal system.\n\nS
 peaker's Biography: Rebecca A. Butcher earned her Ph.D. with Stuart Schrei
 ber at Harvard as an NSF predoctoral fellow. She then pursued postdoctoral
  studies with Jon Clardy at Harvard Medical School\, supported by an NIH N
 RSA postdoctoral fellowship and an NIH Pathway to Independence award. She 
 began her independent career in 2010 in the Department of Chemistry at the
  University of Florida and was promoted to associate professor with tenure
  in 2017. Dr. Butcher is the recipient of a Powe Junior Faculty Enhancemen
 t Award\, a New Scholar in Aging Award from the Ellison Medical Foundation
 \, and a CAREER award from the NSF. She was named a Sloan Fellow by the Al
 fred P. Sloan Foundation and a Cottrell Scholar by the Research Corporatio
 n for Science Advancement.\n\nLab website: https://butcher.chem.ufl.edu/\n
  
LOCATION:https://epfl.zoom.us/j/68173576627
STATUS:CONFIRMED
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