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SUMMARY:Faculty seminar: Organization of gene regulation in a 24 hour peri
 odic world
DTSTART:20220517T121500
DTEND:20220517T131500
DTSTAMP:20260427T212358Z
UID:3fec41e9ab58c70129ed4674ac782749b881fad61bffe58cfe1c23cf
CATEGORIES:Conferences - Seminars
DESCRIPTION:Felix Naef\nAbstract\nLife on Earth is indissociable from 24 h
 our periodicity in our environment\, deeply impacting all scales of biolog
 ical organization from the dynamics of ecosystems\, behavior of individual
 s\,  rhythms in tissue physiology\, to the oscillatory properties of cell
 s and molecules. This organization is coordinated by a molecular oscillato
 r known as the circadian clock\, which plays the role of a metronome to he
 lp organisms resonate with their environment\, and is at the heart of the 
 field of chronobiology. A growing body of evidence shows that perturbation
 s of this temporal organization are detrimental to health. Our lab studies
  systems- and single-cell chronobiology by combining molecular biology and
  biological data science. I will illustrate our approach by summarizing ke
 y results on the regulation of rhythms in gene expression\, focusing on ge
 nome topology and space-time organization of liver physiology at single-ce
 ll scale. Encountered chronobiology data modeling problems\, such as the r
 econstruction of dynamics or assignment of phase coordinates\, benefit fro
 m the periodic structure\, which I will illustrate in the context of our o
 ngoing work on sex-dimorphic and age-dependent human chronobiology.\n\nBio
 \nFelix Naef studied physics at the ETHZ and obtained his PhD from the EPF
 L in 2000. He then received postdoctoral training at the Center for Studie
 s in Physics and Biology at the Rockefeller University. FN has expertise i
 n physics\, systems biology and quantitative analysis of gene regulation\,
  notably related to circadian rhythms and feeding-fasting cycles. He is cu
 rrently Associate Professor at the Institute of Bioengineering (IBI). In 2
 020 he was elected as an EMBO member.\n\nThis seminar is part of the evalu
 ation of Dr Naef for the promotion to full professor.\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/68234169621
STATUS:CONFIRMED
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