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SUMMARY:Morphology and Hemodynamics of the Cortical Blood Supply in Humans
DTSTART:20121011T161500
DTSTAMP:20260924T173806Z
UID:b7ea58df149099183f70cd0fb99ce7cbfcdb7fa54aa1df3269e835be
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Andreas Linninger\nIn the human cortex\, there appears t
 o exist a functional coupling between the neurons in the cortical column a
 nd its bloodsupply. The dynamic mechanisms in response to neuronal activat
 ion triggering increased metabolic oxygen demand and leadingto fast hemody
 namic response to meet this demand are not fully understood. There is evid
 ence that the cortical blood supplyduring functional hyperemia is managed 
 by functional blood units (FBU). Each FBU typically consists of a single c
 entraldraining vein with a diameter of about 100um\; around it are three t
 o five ring arterioles with approximately 40um in diameter. Wehave generat
 ed a computational model of an artificially generated three-dimensional re
 presentation of a FBU (see Figure). Themorphometrics of our artificially g
 enerated FBU closely matches key anatomical properties of the microvascula
 ture of thehuman cortex including capillary density\, distribution\, lengt
 h\, and angle spectra. We have evaluated the cerebralmicrocirculation with
  a morphologically accurate hemodynamic flow model. Results from simulatio
 n on the FBU show thedetailed map of the contrast transit times and concen
 trations\, blood pressures\, volumetric flow rates\, and velocities.
LOCATION:BM 1130 https://plan.epfl.ch/?room==BM%201130
STATUS:CONFIRMED
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