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SUMMARY:EPFL BioE Talks SERIES "Modular Hydrogels in Organoid-Based Diseas
 e Modelling"
DTSTART:20220502T160000
DTEND:20220502T170000
DTSTAMP:20260916T085034Z
UID:18b12fa3e560d5fa4ccd6f3adc3386fde178615a2c43039d0fde5e0e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Eileen Gentleman\, Centre for Craniofacial & Regenerative 
 Biology\, King's College London (UK)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbs
 tract:\nPathological matrix remodelling plays a central role in many human
  diseases\, but is challenging to study as in vitro models often cannot re
 plicate the complex 3D cell-matrix interactions that drive pathologies. In
  this seminar\, I will discuss how we built a 3D model of the human gut th
 at allowed us to uncover an unexpected role for a rare immune cell type ca
 lled ILC1 in driving gut fibrosis in patients with inflammatory bowel dise
 ases. We used molecular dynamics simulations to design PEG hydrogels that 
 cross-link quickly\, but can still mimic the stiffness of normal intestina
 l tissue. We then co-cultured encapsulated human intestinal organoids with
  ILC1\, and using a combination of atomic force microscopy and spectroscop
 y and multiple particle tracking micro-rheology\, found that ILC1 drive in
 testinal matrix remodelling through a balance of MMP9-mediated matrix degr
 adation and TGFβ1-driven fibronectin deposition. Our findings demonstrate
  the potential of using hydrogels in disease modelling\, and open the poss
 ibility of unravelling how pathological matrix remodelling contributes to 
 disease.\n\nBio:\nEileen Gentleman is a Reader in Bioengineering in the Ce
 ntre for Craniofacial and Regenerative Biology at King’s College London.
  She joined Imperial College London in 2005 as post-doctoral research asso
 ciate after completing her PhD in Biomedical Engineering at Tulane Univers
 ity (USA). In 2011\, she was awarded a Wellcome Trust Research Career Deve
 lopment Fellowship and established her lab at King’s with a focus on dev
 eloping materials with modifiable physical and biological properties to di
 rect cellular responses for regenerative applications and to create diseas
 e models. She has received funding awards from the Wellcome Trust\, the Me
 dical Research Council\, and the Engineering and Physical Sciences Researc
 h Council (UK). In 2013 her work in regenerative medicine was recognised w
 ith a prestigious Philip Leverhulme Prize.\n\n\nZoom link (with one-time r
 egistration for the whole series) for attending remotely: https://go.epfl.
 ch/EPFLBioETalks\n\n\nInstructions for 1st-year Ph.D. students who are und
 er EDBB’s mandatory seminar attendance rule:\nIF you are not attending i
 n-person in the room\, please make sure to\n\n	send D. Reinhard a note bef
 ore noon on seminar day\, informing that you plan to attend the talk onlin
 e\, and\n	be signed in on Zoom with a recognizable user name (not a pseudo
 nym making it difficult or impossible to be identified).\n\nStudents atten
 ding the seminar in-person should collect a confirmation signature after t
 he talk - please print your own signature sheet beforehand (71 kB pdf avai
 lable for download here).
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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