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SUMMARY:Alzheimer’s Drug Discovery Foundation – Accelerating Drug Disc
 overy for Frontotemporal Degeneration| Research Funding
DTSTART;VALUE=DATE:20220520
DTSTAMP:20260610T054342Z
UID:e352c2fa32210584c861fdbb640e42858edbe4cecaa3d51bfec02c6c
CATEGORIES:Call for proposal
DESCRIPTION:Aim:  There are currently no FDA approved disease-modifying t
 reatments available for frontotemporal dementia (FTD)\, and symptomatic tr
 eatments only provide limited benefit for patients. Recent scientific adva
 nces have provided an increased understanding of pathogenic mechanisms und
 erlying FTD and are driving the development of potential disease-modifying
  therapies. The Alzheimer’s Drug Discovery Foundation (ADDF) and The Ass
 ociation for Frontotemporal Degeneration (AFTD) seek to accelerate this pr
 ogress by supporting innovative small molecule and biologic (antibodies\, 
 oligonucleotides\, peptides\, gene therapy etc.) drug development programs
  for FTD through this request for proposals (RFP).\n\nThe funding prioriti
 es for this RFP are:\n\n	Lead optimization of novel disease-modifying comp
 ounds\, including medicinal chemistry refinement and in vitro ADME.\n	In v
 ivo testing of novel lead compounds\, biologics\, vaccines\, or repurposed
  drug candidates in relevant animal models for pharmacokinetics\, dose-ran
 ge finding\, target engagement\, in vivo efficacy\, and/or preliminary rod
 ent tolerability studies.\n\n\nFunding:       max. $150\,000\n\nDurat
 ion:      1 year\, with potential for follow-up funding\n\nEligibility
 : Funding is open to researchers and clinicians worldwide at academic medi
 cal centers and universities or nonprofits. Industry partnerships are enco
 uraged.\n\nHow to Apply: Applications are reviewed in a two-step process: 
 Letters of Intent (LOI) are the first step\, and are submitted through the
  ADFF Funding Portal. ADDF’s science team will evaluate LOIs to determin
 e whether the proposed project is consistent with the ADDF's mission and f
 unding priorities. LOI decisions will be sent within three weeks of submis
 sion. Step 2 is an invited full proposal\, which should include a detailed
  project narrative\, budget and justification\, and biographical informati
 on.  When formulating the budget\, note that the following costs are not 
 covered: Indirect costs/Overhead\, Publication costs\, Equipment\, and Tra
 vel.\n\nDeadlines:    20-May-2022 (letter of intent)\n        
                 30-July-2022 (full proposal\, by invitation
 )\n\nFurther information\n\n\n	More information about the program is avail
 able here\n	Detailed application instructions are here\n	The application p
 ortal can be found here\n	For any other questions\, please contact the Res
 earch Office\n
LOCATION:
STATUS:CONFIRMED
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