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SUMMARY:MEchanics GAthering -MEGA- Seminar: Robot-assisted microsurgery to
  study mechanics of morphogenesis
DTSTART:20220519T161500
DTEND:20220519T173000
DTSTAMP:20260916T060156Z
UID:29193b3ee68a423114d56c1e179ad5b0be0405e17482b7d00954364b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ece Ozelci (MICROBS\, EPFL)\nAbstract Microsurgical techniqu
 es that were foundational for experimental embryology in the early 1900s a
 re still in use today. Inspired by these classic techniques we built a use
 r-friendly robotic microsurgery platform that allows precise mechanical ma
 nipulation of soft tissues. As a proof of principle\, we investigated the 
 contribution of different embryonic tissues to vertebrate anteroposterior 
 axis elongation and segmentation by using zebrafish embryos. We repeatedly
  targeted specific regions of tail explants\, and quantified the response 
 in real-time by following morphogenesis of different tissue parts and segm
 entation clock dynamics. We found an extension force generated through the
  posterior notochord that is strong enough to buckle the structure. We pro
 pose that the unidirectional elongation of the notochord and the tail depe
 nds on the posterior region of the notochord experiencing gripping forces 
 applied by the surrounding posterior presomitic mesoderm (PSM). Our result
 s complement existing biomechanical models of axis elongation and reveal t
 hat tail elongation at the observed developmental stage is driven by coupl
 ed interactions between three units: the posterior notochord\, the posteri
 or PSM and the notochord progenitor domain. We also showed that somite pat
 terning is robust against structural perturbations.\n\nBio Ece graduated 
 from Bilkent University with Mechanical Engineering degree in 2016. She ob
 tained her master’s degree in Mechanical Engineering from EPFL in 2018 f
 ocusing on fluid dynamics. Then\, she started her PhD in 2018 as a joint s
 tudent between MICROBS with Prof. Sakar and Oates Lab in SV with Prof. Oat
 es. Her research focuses on the usage of microrobotics to understand mecha
 nics of the body axis development of vertebrates.
LOCATION:MED 2 2423 https://plan.epfl.ch/?room==MED%202%202423 https://epf
 l.zoom.us/j/65022317743?pwd=alFuM0NVUUdxWWpRT0ZxeDUxa0lmUT09
STATUS:CONFIRMED
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