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VERSION:2.0
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SUMMARY:Bioengineering seminar: "Dynamic Allosteric Response in Protein Co
 mplexes - The role of hydrogen bonded water networks"
DTSTART:20220915T140000
DTEND:20220915T150000
DTSTAMP:20260407T020844Z
UID:d38cf0b31514bbdbbecb811bb027d75243aa6323d844febe70df23f6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Scott Prosser\, University of Toronto Distinguished
  Professor of Biophysical Chemistry\nAbstract:\nProtein folding is general
 ly regarded as being driven by “hydrophobic collapse” – as the ribos
 ome releases the nascent protein\, secondary structure is rapidly acquired
  while tertiary structure is derived through the formation of van der Waal
 s interactions between hydrophobic side chains and the simultaneous libera
 tion of water molecules. Yet\, in the final analysis\, salt links and inte
 rnal hydrogen bonds contribute nearly as much to the free energy of foldin
 g as hydrophobic forces. A key player in these hydrogen bonds is water and
  buried water molecules in hydrophobic interiors have the possibility of c
 ontributing to fold stability while also facilitating allostery and functi
 onal dynamics. Beginning with high-resolution crystal structures and comp
 utational analysis we consider water-mediated allostery in a dimeric enzym
 e\, fluoroacetate dehalogenase\, and a 7-transmembrane receptor\, adenosi
 ne A2A. In both cases\, we find networks of water molecules in hydrophobi
 c environments. Computational studies\, NMR\, and functional assays revea
 l their dynamic role in assisting in functional dynamics and facilitating
  action of the protein in response to ligands and substrates.\n\n\nBio:\
 nProfessor Scott Prosser\nProfessor of Chemistry and Biochemistry\, Univ
 ersity of Toronto since 2000\n\nAssistant Professor of Chemistry\, Kent S
 tate University\n\nPostdoc\, University of California\, R Vold\n\nPostdoc\
 , University of Stuttgart G Kothe\n\nPhD University of Guelph\n\n \n\nR
 esearch focus - 19F NMR\, GPCRs and signal transduction\, enzymology\, fun
 ctional dynamics and allostery\, drug screening\, and biophysical chemistr
 y of GPCRs\n\n2017 Royal Society of Chemistry Jeremy Knowles Award for Adv
 ances in Chemical Biology\n2019 University of Toronto Professor in Biophys
 ical Chemistry\n2022 Canadian Society for Chemistry. Biological and Medici
 nal Chemistry Lectureship Award\n2022 AstraZeneca Endowed Chair in Biotech
 nology\, University of Toronto.    
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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