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SUMMARY:ChemBio e-seminar by Prof. Ken Yokoyama
DTSTART:20221025T161500
DTEND:20221025T171500
DTSTAMP:20260415T125755Z
UID:a1c9c31ddbd9040ebef2298e3d73d11600a86dc7a2161a5a6bb0a995
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ken Yokoyama\n\nDuke University\, North Carolina\, USA\n
 Title: Mechanism of radical-mediated C-C bond formation in molybdenum cofa
 ctor biosynthesis and human disease\n\nAbstract:\nMolybdenum cofactor (Moc
 o) is a redox-active enzyme cofactor found in almost all organisms from al
 l kingdoms of life.  Unlike many cofactors\, Moco cannot be taken up as a
  nutrient and requires de novo biosynthesis.  Thus\, Moco biosynthesis is
  an essential process for many organisms including humans and pathogenic b
 acteria.  In humans\, Moco is essential for the healthy development of th
 e brain and genetic mutations in these biosynthetic enzymes cause a fatal 
 metabolic disorder\, Moco deficiency.  During biosynthesis\, the pterin b
 ackbone structure of Moco is constructed from guanosine 5’-triphosphate 
 (GTP) via a unique rearrangement.  In the past decade\, we have discovere
 d the functions of two enzymes (MoaA and MoaC) responsible for this tran
 sformation and have made significant progress toward understanding their c
 atalytic mechanisms and how their mutations cause human disease.  In this
  seminar\, I will present some of the recent progress we have made in the 
 past ~5 years.\n\nSpeaker's biography:\nProf. Yokoyama received Ph.D. from
  the Tokyo Institute of Technology by studying the mechanism of biosynthes
 is of aminoglycoside antibiotics and performed a postdoc study with Prof. 
 JoAnne Stubbe at MIT\, where he studied the mechanism of long-range radica
 l propagation in ribonucleotide reductase (RNR) using unnatural tyrosine a
 nalogs to trap pathway radical species.  As an independent researcher at 
 Duke University\, Prof. Yokoyama has been studying the biosynthesis of nat
 ural products and cofactors that involve unique metalloenzymes including r
 adical SAM enzymes\, as well as the mechanism of fungal cell wall biosynth
 esis.\n\nLab website: http://sites.duke.edu/yokoyamalab/
LOCATION:https://epfl.zoom.us/j/67321697618
STATUS:CONFIRMED
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