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VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:IMX Seminar Series - Supramolecular Polymers
DTSTART:20221219T131500
DTEND:20221219T141500
DTSTAMP:20260510T202414Z
UID:76e778d74b00b18e60d559897b53cebe1f71492a67339e886bc092b1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Tanja Weil\, Max Planck Institue\, Germany\nMaterials Ta
 lking to Cells\nWouldn't it be great if we could design soft materials tha
 t actively integrate into cells or tissues and stimulate cellular response
 s? Can we imagine materials that instruct cells to grow\, proliferate or i
 nduce apoptosis? What would such materials look like and would we be able 
 to learn the language of cells and translate it into communicating materia
 ls? In my talk\, I will first discuss how to design structurally precise p
 olymeric nanostructures using the DNA origami technique. I will then prese
 nt the identification of bioactive peptide nanostructures that stimulate t
 he growth of neuronal cells without growth factors or the concentration of
  viruses at the cell membrane\, which is of interest for applications in r
 egenerative medicine and gene therapy. Controlled formation of peptide nan
 ostructures in the cytoplasm by chemical cascade reactions opens new avenu
 es as metabolic inhibitors for cancer therapy.\nFigure taken from W.J. Par
 ak\, T. Weil\, P.S. Weiss\, ACS Nano 2021\, 15\, 10\, 15397-15401\n1. Chag
 ri\, S. et al. Designing Bioresponsive Nanomaterials for Iintracellular Se
 lf-Assembly. Nature Reviews Chemistry 2022\, 6\, 320–338.\n2. Zhou\, Z. 
 et al. Polymer Chemistry in Living Cells. Accounts of Chemical Research 20
 22\, 55 (20) 2998-3009.\n3. Winterwerber\, P. et al. Multi-Wavelength Phot
 opolymerization of Stable Poly(Catecholamines)-DNA Origami Nanostructures.
  Angewandte Chemie International Edition 2022\, 61 (8)\, e202111226.\n4. S
 ieste\, S. et al. Supramolecular Peptide Nanofibrils with Optimized Sequen
 ces and Molecular Structures for Efficient Retroviral Transduction. Advanc
 ed Functional Materials 2021 31 2009382.\n5. Pieszka\, M. et al. Controlle
 d Supramolecular Assembly inside Living Cells by Sequential Multi-staged C
 hemical Reactions. Journal of the American Chemical Society 2020 142 (37) 
 15780–15789.\n6. Zhou\, Z. et al. In Situ Assembly of Platinum (II)-Meta
 llopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabol
 ism. Journal of the American Chemical Society 2022\, 144 (27) 12219-12228.
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
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