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SUMMARY:cGAS/STING-dependent immunity in drosophila: evolutionarily conser
 ved aspects and innovations
DTSTART:20220920T121500
DTEND:20220920T131500
DTSTAMP:20260930T185413Z
UID:cb5ee786f63f1fed6914cc8db2bc46d2518bf15428b8cb99ad1c5967
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jean-Luc Imler\, Institute of Molecular and Cell Biology\, CNR
 S/Université de Strasbourg\nThe cGAS-STING pathway plays a central role i
 n the detection of DNA in the cytosol of mammalian cells and activation of
  immunity. Although the early evolutionary origin of this pathway in anima
 ls has been noted\, its ancestral functions have remained elusive so far.
  Recent findings in invertebrates establish a role in sensing and signa
 ling infection\, triggering potent transcriptional responses\, in addition
  to autophagy. In particular\, results from flies and moths/butterflies po
 ints to the importance of STING signaling in antiviral immunity in insects
 . The recent characterization of cGAS-like receptors in Drosophila reveals
  the plasticity of this family of pattern-recognition receptors\, able to 
 accommodate ligands different from DNA and to produce cyclic dinucleotides
  beyond 2′3′-cGAMP.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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