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SUMMARY:EESS talk on "Electron Transfer at the Microbe-Mineral Interface"
DTSTART:20230221T121500
DTEND:20230221T131500
DTSTAMP:20260611T020506Z
UID:1e3bb4b248e0a165da797b82e57c60418b18d2d52fbfd2f6e4e0b734
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Marcus J. Edwards\, School of Life Sciences\, University of
  Essex\, Colchester\, UK\nAbstract:\nMany bacteria can exchange electrons 
 with redox-active elements in the environment\, such as iron\, manganese a
 nd uranium. For Gram-negative dissimilatory metal-reducing bacteria (DMRB)
 \, such as Shewanella and Geobacter\, this exchange involves transferring 
 electrons across the outer membrane of the cell\, making DMRB of great int
 erest not only for their influence on the biogeochemical cycling of redox-
 active elements but also for their potential exploitation in biotechnologi
 cal applications including microbial fuel cells\, biosensors and microbial
  electrosynthesis.\nEstablishing the molecular details of how electrons ar
 e transported across the bacterial outer membrane has been the subject of 
 intensive research over the last 30 years. In the case of Shewanella\, a 
 heterotrimeric membrane protein complex\, MtrCAB\, was identified to be re
 quired for extracellular electron transfer. We have reported the first str
 ucture of the MtrCAB porin-cytochrome complex revealing a 185 Å long wire
  formed by 20 c-type hemes scaffolded by two cytochromes\, MtrA and MtrC\,
  and a porin\, MtrB\, which embeds within the outer membrane. Subsequent b
 ioinformatic and experimental studies have revealed the wide-spread nature
  of the porin-cytochrome electron conduit and how electron transfer across
  the outer membrane can be fine-tuned at the molecular level.\n\nShort bio
 graphy:\nDr Edwards is a lecturer in the School of Life Sciences at the Un
 iversity of Essex (UK) where his research focusses upon resolving the mole
 cular details of bacterial extracellular electron transfer utilizing a com
 bination of biochemical\, electrochemical and structural techniques.\nHe c
 arried out his Ph.D. in structural biochemistry at the John Innes Centre f
 or Plant and Microbial Science (UK). He subsequently took up a postdoctora
 l position at the University of East Anglia (UK) working on a U.S. Departm
 ent of Energy funded project in collaboration with the Pacific Northwest N
 ational Laboratory (WA\, USA) focusing on the electron transfer pathways o
 f dissimilatory metal reducing bacteria. In 2020\, he moved to take up a p
 ermanent position at the University of Essex where he is in the process of
  establishing his laboratory.\n 
LOCATION:GC B1 10 https://plan.epfl.ch/?room==GC%20B1%2010 https://epfl.zo
 om.us/j/64582412219
STATUS:CONFIRMED
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