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SUMMARY:Probing life and death decisions with synthetic protein chemistry
DTSTART:20221122T161500
DTEND:20221122T180000
DTSTAMP:20260502T000257Z
UID:e8a25e0d1b8c26774c8aea883a38a95ae5c9cc0e0ec4c8fc80ad818d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Manuel Müller (King's College London)  \nPost-translat
 ional modifications (PTMs) of proteins control almost all biological proce
 sses\, including cellular life and death decisions. Such processes serve t
 o eliminate aberrant cells and are mediated by endogenous proteins - inclu
 ding the tumour suppressor p53 -\, and can be hijacked by pathogen-encoded
  toxic proteins. Deciphering how PTMs regulate the activity of these “se
 lf-destruction” proteins is an important step in understanding the basic
  biology of controlled cell death and in providing a framework for the des
 ign of new antitumour proteins. However\, mechanistic analysis of how PTMs
  effect structural and functional changes is hampered by the complexity of
  the underlying signalling pathways and thus requires chemistry-driven app
 roaches which we develop. I will discuss our protein semisynthesis strateg
 ies to access “designer p53” and a viral anticancer protein bearing de
 fined PTMs\, and how were are deploying these proteins in functional assay
 s in vitro and in living cells to gain new insights into how PTMs decide c
 ell fate.   TBA
LOCATION:CH B3 31 https://plan.epfl.ch/?room==CH%20B3%2031
STATUS:CONFIRMED
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