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SUMMARY:MechE Colloquium: Folds\, Rolls and Swirls of cells: Reconstitutin
 g Morphogenesis in Vitro
DTSTART:20221115T120000
DTEND:20221115T130000
DTSTAMP:20260924T153240Z
UID:c3b67383e10b1f5a15771bd49e6ff0db09b6750cb57209d8c4befeeb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Aurélien Roux\, School of Chemistry and Biochemistry\, 
 University of Geneva (UNIGE)\nAbstract: In order to understand basic mecha
 nisms of tissue morphogenesis\, my lab developed in vitro assays to study 
 the self-morphogenesis of cell assemblies under various constraints. In pa
 rticular\, we show that proliferation pressure rising inside an epithelium
  growing under confinement is sufficient for it to buckle. When cell layer
 s are rolled\, they transiently swell up to 50% of their initial volume. A
 lso\, myoblasts spontaneously organise into spirals when confined onto a s
 urface\, and proliferate into a vortex that further grows as a tornado. I 
 will discuss how these in vitro process could be relevant for the understa
 nding of embryonic development.\n\nBiography: Aurélien Roux studied biolo
 gy at the Ecole Normale Supérieure de Lyon\, France (1997-1999)\, with a 
 minor in Physics. He did a Master of Physics\, University Denis Diderot\, 
 Paris (1999-2000). As a Ph.D student with Patricia Bassereau and Bruno Gou
 d (Curie Institute\, Paris\, 2000-2004)\, he studied how lipids can be sor
 ted by membrane curvature. He then did his post-doctoral work with Pietro 
 de Camilli (2004-2007\, Yale\, USA)\, reconstituting in vitro dynamin medi
 ated membrane fission\, which he continued as a CNRS staff scientist (Inst
 itut Curie\, Paris\, 2007-2010). Appointed assistant professor of Biochemi
 stry\, Geneva (2010-2015)\, he expanded his work towards ESCRT-III\, the m
 ost ancient and ubiquitous fission machinery in the cell. In 2016\, he was
  tenured to associate professor at Unige\, and then Full professor in 2020
 . During this period\, he developed assays to reconstitute spontaneous mor
 phogenesis of cellular assemblies in vitro.
LOCATION:MED 0 1418 https://plan.epfl.ch/?room==MED%200%201418 https://epf
 l.zoom.us/j/65387864766
STATUS:CONFIRMED
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