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SUMMARY:EPFL BioE Talks SERIES  "Symmetry Breaking and Crypt Morphogenesis
  in Intestinal Organoids"
DTSTART:20221107T160000
DTEND:20221107T170000
DTSTAMP:20260925T120337Z
UID:e54db04ceb6fa931aa34e3d6c7296ad744cba2006fa81db66d0b71a9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Prisca Liberali\, University of Basel and Friedrich Mies
 cher Institute for Biomedical Research\, Basel (CH)\nWEEKLY EPFL BIOE TALK
 S SERIES\n\nAbstract:\nMulticellular organisms are composed of cells and t
 issues with identical genomes but different properties and functions. They
  all develop from one cell to form multicellular structures of astounding 
 complexity. During development\, in a series of spatio-temporal coordinate
 d steps\, cells differentiate into different cell types and establish tiss
 ue-scale architectures and functions. Throughout life\, continuous tissue 
 renewal and regeneration is required for tissue homeostasis\, which also r
 equires fine-tuned spatio-temporal coordination of cells. I will discuss h
 ow cellular interactions generate the specific contexts and spatio-tempora
 l coordination underlying development and regeneration and how we specific
 ally investigate what are the molecular and physical mechanisms that allow
  a cell\, in a tissue\, to sense its complex environment\, to take individ
 ual coordinated decisions. Moreover\, I will discuss the molecular mechani
 sms of intestinal organoid self-organization and the role of cell-to-cell 
 variability in populations of differentiating cells during symmetry breaki
 ng.\n\nBio:\nPrisca Liberali has been trained as a physical organic chemis
 t with a focus on the dynamical understanding of organic chemical reaction
 s. She then changed fields for her PhD and became a molecular cell biologi
 st. She has developed single-cell methods to study cell-to-cell variabilit
 y and its involvement in the emergence of complex cellular traits. Since a
  few years she has become fascinated by the role of self-organisation in c
 ollective cell behaviours\, and how these can control intracellular signal
 ling in single cells. Because these emergent phenomena have multiple layer
 s of biological organisation at different scales\, she believes that novel
  experimental\, quantitative and statistical methods are required to integ
 rate our understanding of single-cell biology. Currently\, she is a profes
 sor at the Friedrich Miescher Institute (FMI) with a lab focused on dynami
 cs of self-organisation\, and on how cellular signalling dictates its spat
 ial-temporal regulation.\n\n\nZoom link (with one-time registration for th
 e whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n
 \n\nInstructions for 1st-year Ph.D. students who are under EDBB’s mandat
 ory seminar attendance rule:\nIF you are not attending in-person in the ro
 om\, please make sure to\n\n	send D. Reinhard a note before noon on semina
 r day\, informing that you plan to attend the talk online\, and\n	be signe
 d in on Zoom with a recognizable user name (not a pseudonym making it diff
 icult or impossible to be identified).\n\nStudents attending the seminar i
 n-person should collect a confirmation signature after the talk - please p
 rint your own signature sheet beforehand (71 kB pdf available for download
  here).\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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