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SUMMARY:Liver regeneration: insight into two critical issues
DTSTART:20221108T093000
DTEND:20221108T103000
DTSTAMP:20260405T120521Z
UID:b638242b1d65a3717a04611425934458214a47489526b2b4da7991d2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Isabelle LECLERCQ\, M.D.\, Ph.D.\n\nUC Louvain\, Belgium\n
 The liver has an extraordinary capacity to rapidly and efficiently regener
 ate in case of removal of a portion of the liver mass or acute destruction
  of part of the parenchymal hepatocytes. This occurs through a well-orches
 trated process that calls into action many cellular and molecular players 
 and requires the effective operation of several sensors.\nLiver regenerati
 on renders possible the surgical resection of liver tumours as well as liv
 er transplantation. However\, when the resected liver mass is too large\, 
 and the remnant liver or liver graft is too small\, the patient risks post
 operative liver failure. This is called the small-for-size syndrome. I wil
 l review what we know about the pathogenesis of the small-for-size syndrom
 e\, and what we learned from pro-regenerative surgical approaches. I will 
 present experimental data that shed light on a new paradigm and how it cou
 ld be exploited for therapeutic purposes.\nLiver regeneration also enables
  full recovery of liver architecture and function after acute hepatitis bu
 t\, when the injury is chronic and the hepatocytes are poorly functional\,
  the process faces exhaustion and liver failure occurs. The biliary epithe
 lium provides facultative progenitor cells whose differentiation into hepa
 tocytes offers an alternative mechanism to fuel the diseased liver with fu
 nctional hepatocytes even though the efficiency and magnitude of the proce
 ss are limited. Sox 9\, is a transcription factor that dictates the biliar
 y identity. I will report ongoing work exploring the effects of SOX9 manip
 ulation on biliary-driven liver regeneration.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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