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SUMMARY:IEM Seminar Series: Digital sensing with CMOS-based nanocapacitor 
 arrays: Formation of lipid-supported bilayers as case study
DTSTART:20221207T150000
DTEND:20221207T160000
DTSTAMP:20260406T050728Z
UID:ede57a952c8a3b86cc49ff6e81c95d38d4dd907a52f48173efa510c7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Serge G. Lemay\nUniversity of Twente\, Faculty of Science and 
 Technology & MESA+ Institute for Nanotechnology\nAbstract\nWhile represent
 ing the ultimate limit in mass sensitivity for a given analyte\, single-en
 tity electrochemical (bio)sensors typically have limited concentration sen
 sitivity due to their small physical dimensions. One route to overcoming t
 his hurdle is to employ large numbers of parallelized devices\, each capab
 le of single-entity detection.  An example of such an architecture is CMO
 S-based nanocapacitor arrays\, which allow locally probing the impedance o
 f an electrolyte in real time and with sub-micron spatial resolution. At s
 ufficiently high frequencies the electric field penetrates beyond the elec
 trical double layer caused by screening ions\, allowing a form of electroc
 hemical imaging of micron-sized synthetic and biological entities. For nan
 oscale analytes\, on the other hand\, the response takes the form of discr
 ete\, step-like changes in impedance upon binding to the surface of an ele
 ctrode. Here we illustrate these capabilities by monitoring in real time t
 he formation of a supported lipid bilayer from the fusion of lipid vesicle
 s. Several nanoscale vesicles are detected as they impinge upon the surfac
 e of each individual electrode and gradually cover its surface. Even thoug
 h the impedance signal at each of the 216 electrodes is stochastic in natu
 re\, the total response exhibits the smooth behavior expected for the form
 ation of a macroscopic lipid bilayer. This work is a collaboration with NX
 P Semiconductors.\n\nBio\nSerge G. Lemay received a B.A.Sc. in Electrical 
 Engineering with minor in Physics from the University of Waterloo\, Canada
 \, in 1993\, and a Ph.D. in Physics from Cornell University\, USA\, in 199
 9. He was faculty at Delft University of Technology\, The Netherlands\, fr
 om 2001 to 2009. In 2009 he relocated to the University of Twente\, The Ne
 therlands\, where he heads the Bioelectronics group\, part of the Faculty 
 of Science and Technology and the MESA+ Institute for Nanotechnology. His 
 research has spanned solid-state physics (charge-density waves)\, molecula
 r electronics (quantum effects in carbon nanotubes) and biophysics (DNA el
 ectrostatics). His main interests at present include the fundamentals of e
 lectron transfer in liquid\, in particular electrochemical nanofluidic dev
 ices\, and exploring digital transduction mechanisms for biosensing.\n 
LOCATION:ME B3 31 https://plan.epfl.ch/?room==ME%20B3%2031 https://epfl.zo
 om.us/j/64861531725
STATUS:CONFIRMED
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