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SUMMARY:Dynamical landscapes of cell fate decisions
DTSTART:20221214T153000
DTEND:20221214T164500
DTSTAMP:20260507T065512Z
UID:3c2f07bd721164fceca372d345354f88e661115a86de6b35e6841e59
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. David Rand\, University of Warwick\, UK\nAbstract. I wil
 l discuss an approach to constructing and validating quantitative dynamica
 l models of cellular differentiation inspired by a revised view of develop
 mental landscapes based on past results from catastrophe theory and new re
 sults about dynamical systems. The theory suggests a new approach to using
  single cell expression data to derive quantitative models that can be use
 d to predict. I will describe an application to vertebrate trunk developme
 nt in which we identify two cell fate decision structures that we believe 
 will be ubiquitous. Collaborators:  James Briscoe\, Robert Blassberg\, El
 ena Camacho-Aguilar\, Francis Corson\, Archishman Raju\,  Meritxell Sae
 z\, Eric Siggia.\n\nDavid started his career as a mathematician making lan
 dmark contributions notably in dynamical systems. In the last years he has
  made a number of impressive contributions to systems and quantitative bio
 logy\, notably on biological oscillators and developmental systems. Notabl
 y his recent work on using geometrical principles to reconstruct potential
  landscape models for developmental systems should interest many of you:\n
 https://doi.org/10.1016/j.cels.2021.08.013\n\nHis publications are listed 
 here:\nhttps://www.davidrand.uk/page2/index.html\n\nProfessor David Rand i
 s Professor of Mathematics at the Mathematics Institute & Zeeman Institute
  for Systems Biology and Infectious Epidemiology Research\, University o
 f Warwick\, UK\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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