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PRODID:-//Memento EPFL//
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SUMMARY:EPFL BioE Talks SERIES  "The Context-Dependent Function of Chromat
 in Modifications"
DTSTART:20221212T160000
DTEND:20221212T170000
DTSTAMP:20260508T120416Z
UID:b971c496e90f9ba1c7730f6c3cf62abc5be579353e820c97b0cab0a7
CATEGORIES:Conferences - Seminars
DESCRIPTION:James Hackett\, Ph.D.\, Group Leader\, EMBL Rome\, Monterotond
 o (IT)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbstract:\nControl of chromatin s
 tructure and accessibility is a central mechanism for the regulation and 
 propagation of gene expression programs. Histone modifications contribute
  to this mechanism\, but their precise role in mediating quantitative 
 transcriptional responses and cellular memory is incompletely understood.
  Indeed\, it remains debated whether chromatin modification states direct
 ly trigger transcription or whether they simply reflect a consequence of
  expression across cellular and genomic environments. Understanding this 
 is important to establish the function of dynamic epigenomic landscapes
  associated with cell identity and fate transitions. Here\, I will first
  present our attempts to deconvolve chromatin regulation at the level of 
 global epigenome (re)programming events during early mammalian developmen
 t. I will then discuss how precision technologies can capture the contex
 t-dependent and quantitative function of chromatin modifications on transc
 riptional regulation and memory.\n\nBio:\nPhD\, 2010\, University of Edin
 burgh\, UK.\nPostdoctoral research at the Gurdon Institute\, University of
  Cambridge\, UK.\nGroup leader at EMBL since 2016.\nJoint appointment with
  the Genome Biology Unit.\n\n\nZoom link (with one-time registration for t
 he whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks\
 n\n\nInstructions for 1st-year Ph.D. students who are under EDBB’s manda
 tory seminar attendance rule:\nIF you are not attending in-person in the r
 oom\, please make sure to\n\n	send D. Reinhard a note before noon on semin
 ar day\, informing that you plan to attend the talk online\, and\n	be sign
 ed in on Zoom with a recognizable user name (not a pseudonym making it dif
 ficult or impossible to be identified).\n\nStudents attending the seminar 
 in-person should collect a confirmation signature after the talk - please 
 print your own signature sheet beforehand (71 kB pdf available for downloa
 d here).\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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