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SUMMARY:BMI Seminar // Fides Zenk - Single-cell epigenomic reconstruction 
 of developmental trajectories in human neural organoid systems
DTSTART:20230118T160000
DTEND:20230118T170000
DTSTAMP:20260506T045011Z
UID:3101571a7b1400908c51ebd5fd82667229d2307958963d991b7d2578
CATEGORIES:Conferences - Seminars
DESCRIPTION:Fides Zenk\, ETHZ\, Zurich / EPFL (starging September)\nThe ce
 ll type diversity of the human body originates from just one single totipo
 tent cell. How the different cell types emerge from the same genomic seque
 nce and how they maintain their identities throughout development is still
  an open question in biology. Epigenetic modifications that can direct the
  activity of genes and regulatory elements during development play an impo
 rtant role in the process of cell identity decisions. Here\, we explore ho
 w brain development and in particular\, the differentiation of progenitor 
 cells into different neuronal and glial branches is regulated by epigeneti
 c mechanisms. We use human multiregion brain organoids to model the earlie
 st events of cell fate acquisition in the developing brain and apply singl
 e-cell epigenetic profiling of histone modifications at various stages of 
 brain and retina organoid development. We use this data to reconstruct the
  epigenetic trajectory governing cell fate acquisition. We find that switc
 hing of epigenetic modifications can precede the activation of important b
 rain region-specific transcription factors. Further\, we show that perturb
 ation of epigenetic modifiers during neuroectoderm establishment disrupts 
 fate decisions and leads to aberrant cell fate acquisition. This ultimatel
 y influences development and cell type composition of brain organoids. In 
 summary\, we provide the first comprehensive single-cell atlas of histone 
 modifications during human brain organoid development\, which will serve a
 s a reference to understand early cell fate decisions and neurodevelopment
 al diseases associated with chromatin regulators.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/62550191552?pwd=OFRDVzBHb0cyVG1wYkxUSFFEMUNPdz09
STATUS:CONFIRMED
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