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SUMMARY:A Protein Condensate Drives Actin-Independent Endocytosis
DTSTART:20230127T110000
DTEND:20230127T120000
DTSTAMP:20260427T230623Z
UID:90822ea8d956141b006a506778bdeab0de7824c7cf9b43bd03288cb1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Steve Michnick\, Professor of Biochemistry at the University o
 f Montréal\nEndocytosis is a process by which living cells absorb materia
 ls from their surrounding and maintain the composition of proteins in thei
 r outer membrane. Endocytosis begins with invagination of the cell surface
  membranes which are eventually pinched off to form endocytic vesicles. Th
 e forces driving the initial invagination have remained a mystery. We have
  discovered that endocytosis could be driven by spontaneous phase separati
 on of endocytic coat proteins on the membrane surface\, which through a ba
 lance of competing adherence between membrane\, cytoplasm and condensate\,
  and cohesion of the condensate reflected in their viscoelastic properties
 \, results in membrane being aspirated into the condensate. This ability o
 f biomolecular condensates to perform work at interfaces may be a common m
 orphogenic mechanism governing vesicle production and trafficking as well 
 as other membrane interfacial phenomena such as the formation of transmemb
 rane pores.\n\nStephen Michnick is Professor of Biochemistry at the Univer
 sité de Montréal and Adjunct Professors of Bioengineering at McGill Univ
 ersity and of Pharmacy at the University of Waterloo. He received his B. S
 c. and Ph. D. from the University of Toronto with Jeremy P. Carver and pos
 tdoctoral training at Harvard University with Profs. Stuart Schreiber and 
 Martin Karplus (Nobel Prize\, Chemistry\, 2013). Prof. Michnick is the Can
 ada Research Chair in Cell Architecture and Dynamics and elected Fellow of
  the Royal Society of Canada and the Royal Society of Chemistry of the UK.
  Prof. Michnick has received several honors\, including in addition to Tie
 r I and II Canada Research Chairs\, Burroughs-Wellcome New Investigator an
 d Medical Research Council of Canada Scientist Awards. The Michnick lab st
 udies principles governing the organization and properties of macromolecul
 ar assemblies in living cells\, including the evolution and dynamics of pr
 otein interaction networks and mechano-active biomolecular condensates. Th
 ey have developed methods to study the spatiotemporal dynamics and topolog
 ies of protein interaction networks\, on different time and space scales.\
 n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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